国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2014年
5期
324-327
,共4页
信号传导%肿瘤%药物耐受性%药物疗法
信號傳導%腫瘤%藥物耐受性%藥物療法
신호전도%종류%약물내수성%약물요법
Signal transduction%Neoplasms%Drug tolerance%Drug therapy
磷脂酰肌醇3-激酶-蛋白激酶B(PI3K-Akt)信号通路对于细胞增殖、分化、凋亡的调节起关键性作用,与细胞的生理功能和某些疾病的发生关系密切.在许多肿瘤中,PI3K-Akt信号通路的过度激活与肿瘤耐药性的产生也密切相关.体外研究表明,使用化疗药物联合PI3K-Akt信号通路抑制剂,可以显著增强化疗药物作用效果、降低IC50值.因此,PI3K-Akt信号通路已成为一个可以逆转化疗耐药的重要靶点.
燐脂酰肌醇3-激酶-蛋白激酶B(PI3K-Akt)信號通路對于細胞增殖、分化、凋亡的調節起關鍵性作用,與細胞的生理功能和某些疾病的髮生關繫密切.在許多腫瘤中,PI3K-Akt信號通路的過度激活與腫瘤耐藥性的產生也密切相關.體外研究錶明,使用化療藥物聯閤PI3K-Akt信號通路抑製劑,可以顯著增彊化療藥物作用效果、降低IC50值.因此,PI3K-Akt信號通路已成為一箇可以逆轉化療耐藥的重要靶點.
린지선기순3-격매-단백격매B(PI3K-Akt)신호통로대우세포증식、분화、조망적조절기관건성작용,여세포적생리공능화모사질병적발생관계밀절.재허다종류중,PI3K-Akt신호통로적과도격활여종류내약성적산생야밀절상관.체외연구표명,사용화료약물연합PI3K-Akt신호통로억제제,가이현저증강화료약물작용효과、강저IC50치.인차,PI3K-Akt신호통로이성위일개가이역전화료내약적중요파점.
PI3K-Akt signaling pathway plays a critical role in the regulation of cell proliferation,differentiation and apoptosis,and is closely related to the physiological function of cells and thus may cause certain diseases.The excessive activation of this pathway is found closely associated with the formation of drug resistance of tumors.Recent studies in vitro indicate that the combined chemotherapy drugs with PI3K-Akt signaling pathway inhibitors,can significantly enhance the efficiency of chemotherapy drug and lower the value of IC50.Therefore,PI3K-Akt signaling pathway has become an important target to inhibit tumor cell growth and reverse tumor drug resistance.
