CAJ | 학술논문

结直肠癌发生是遗传学和表观遗传学改变累积的结果.基因组不稳定导致基因突变和DNA甲基化模式改变是结直肠癌发生的主要分子事件.鉴定不同患者中导致结直肠癌发生的关键基因突变及甲基化表型,对结直肠癌进行分子病理分型和诊断,是进行个体化治疗和靶向治疗的前提.
결직장암발생시유전학화표관유전학개변루적적결과.기인조불은정도치기인돌변화DNA갑기화모식개변시결직장암발생적주요분자사건.감정불동환자중도치결직장암발생적관건기인돌변급갑기화표형,대결직장암진행분자병리분형화진단,시진행개체화치료화파향치료적전제.
Colorectal carcinogenesis is the result of accumulation of genetic and epigenetic alters.Gene mutations and changes in DNA methylation patterns,resulted from genomic instability,are the main molecular events in colorectal cancer.Identification of key mutations and methylation phenotypes in genes leading to colorectal cancer progression,and molecular pathology classification and diagnosis are likely to be the prerequisites for individualized and targeted treatment.