CAJ | 학술논문

1-磷酸鞘氨醇(S1P)是一种具有生物活性的脂质信使,可由鞘氨醇激酶(SphK)催化产生,并作用于1-磷酸鞘氨醇受体(S1PR)介导多种生物学行为.研究表明,SphK、S1P及S1PR的异常与白血病、乳腺癌、结肠癌、淋巴瘤等的发生发展密切相关,S1PR1与信号转导及转录激活子3(STAT3)的相互作用也参与了恶性肿瘤的发病,因而具有潜在的肿瘤治疗价值.
1-린산초안순(S1P)시일충구유생물활성적지질신사,가유초안순격매(SphK)최화산생,병작용우1-린산초안순수체(S1PR)개도다충생물학행위.연구표명,SphK、S1P급S1PR적이상여백혈병、유선암、결장암、림파류등적발생발전밀절상관,S1PR1여신호전도급전록격활자3(STAT3)적상호작용야삼여료악성종류적발병,인이구유잠재적종류치료개치.
Sphingosine-1-phosphate (S1 P) is a kind of bioactive messenger which is catalyzed by sphingosine kinases (SphK) and mediates various biological behaviors through binding to sphingosine-1-phosphate receptors(S1PR).Researches demonstrate that the aberration of SphK,S1P and S1PR is closely related to the occurrence and development of cancers,such as leukemia,breast cancer,colorectal cancer and lymphoma.The interaction between S1PR1 and signal transducer and activator of transcription 3 (STAT3) is shown to take part in the pathogenesis of malignant tumors as well.Therefore,they are considered to have the potential tumor-treatment value.