CAJ | 학술논문

缺氧诱导因子-1α(HIF-1α)是一种细胞缺氧应答调控因子,在多种恶性肿瘤中呈高表达.研究表明,HIF-1α在上皮间质转化(EMT)过程中发挥重要作用,它可通过一系列信号通路及作用机制多方面、多层次地调控EMT的发生,参与肿瘤的侵袭和转移.探寻HIF-1α调控EMT相关机制对开发新的、有效的肿瘤治疗方法有重要意义.
결양유도인자-1α(HIF-1α)시일충세포결양응답조공인자,재다충악성종류중정고표체.연구표명,HIF-1α재상피간질전화(EMT)과정중발휘중요작용,타가통과일계렬신호통로급작용궤제다방면、다층차지조공EMT적발생,삼여종류적침습화전이.탐심HIF-1α조공EMT상관궤제대개발신적、유효적종류치료방법유중요의의.
Hypoxia inducible factor (HIF-1α) is a hypoxia response regulator,which is highly expressed in malignant tumors.Researches have shown that HIF-1α plays an important role in epithelial mesenchymal transformation.It can regulate epithelial mesenchymal transition through a series of signal pathways and mechanisms at many levels,to participate in the invasion and metastasis of tumors.To explore the mechanism of HIF-lα controlling epithelial mesenchymal transformation has important significance for the development of new,effective tumor treatment methods.