国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2014年
6期
439-443
,共5页
肺疾病,慢性阻塞性%肺肿瘤%吸烟%炎症
肺疾病,慢性阻塞性%肺腫瘤%吸煙%炎癥
폐질병,만성조새성%폐종류%흡연%염증
Pulmonary disease,chronic obstructive%Lung neoplasms%Smoking%Inflammation
肺癌和慢性阻塞性肺病(COPD)是全球高死亡率的疾病.流行病学研究表明,COPD可增加患肺癌的风险.COPD和肺癌皆可由吸烟引起,且这两种疾病常常发生在同一患者身上.但两种疾病之间的联系不仅仅是吸烟,其病理机制联系还包括遗传易感性、炎症反应、细胞损伤、氧化与毒性应激、细胞外基质和蛋白酶的分泌等.其中的一些共性可能成为这两种疾病的化学预防或化学治疗的靶点.
肺癌和慢性阻塞性肺病(COPD)是全毬高死亡率的疾病.流行病學研究錶明,COPD可增加患肺癌的風險.COPD和肺癌皆可由吸煙引起,且這兩種疾病常常髮生在同一患者身上.但兩種疾病之間的聯繫不僅僅是吸煙,其病理機製聯繫還包括遺傳易感性、炎癥反應、細胞損傷、氧化與毒性應激、細胞外基質和蛋白酶的分泌等.其中的一些共性可能成為這兩種疾病的化學預防或化學治療的靶點.
폐암화만성조새성폐병(COPD)시전구고사망솔적질병.류행병학연구표명,COPD가증가환폐암적풍험.COPD화폐암개가유흡연인기,차저량충질병상상발생재동일환자신상.단량충질병지간적련계불부부시흡연,기병리궤제련계환포괄유전역감성、염증반응、세포손상、양화여독성응격、세포외기질화단백매적분비등.기중적일사공성가능성위저량충질병적화학예방혹화학치료적파점.
Lung cancer and chronic obstructive pulmonary disease (COPD) are two high-mortality diseases in the world.Numerous epidemiological studies have demonstrated that presence of COPD increases the risk of lung cancer.Habitual cigarette smoking frequently develops lung cancer as well as COPD,However the links between the two diseases should be more than smoking alone.The underlying mechanisms may include genetic predisposition,inflammation and cell injury,oxidative and noxious stress,extracellular matrix and proteinases,some of which might represent the targets for chemoprevention or chemotherapy.
