国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2014年
6期
460-463
,共4页
白血病%治疗%JAK/STAT信号通路
白血病%治療%JAK/STAT信號通路
백혈병%치료%JAK/STAT신호통로
Acute leukemia%Therapy%JAK/STAT pathway
JAK/STAT信号通路是由多种细胞因子与受体结合激活的中心通路,参与肿瘤的增殖、分化和凋亡过程.研究表明,血液细胞中JAK/STAT突变及调控异常对急性白血病发生发展起重要作用.探讨此通路的异常有望为治疗急性白血病提供新靶点.
JAK/STAT信號通路是由多種細胞因子與受體結閤激活的中心通路,參與腫瘤的增殖、分化和凋亡過程.研究錶明,血液細胞中JAK/STAT突變及調控異常對急性白血病髮生髮展起重要作用.探討此通路的異常有望為治療急性白血病提供新靶點.
JAK/STAT신호통로시유다충세포인자여수체결합격활적중심통로,삼여종류적증식、분화화조망과정.연구표명,혈액세포중JAK/STAT돌변급조공이상대급성백혈병발생발전기중요작용.탐토차통로적이상유망위치료급성백혈병제공신파점.
JAK/STAT is a central signaling pathway activated by cytokines binding with their respective receptors which can regulate cell proliferation,differentiation and apoptosis.Recent studies have suggested that abnormal signaling pathway with gene mutation and dysregulation plays an important role in the pathogenesis and progression of acute leukemia.The investigation of this pathway may provide novel target for therapies of acute leukemia.
