国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2013年
1期
40-42
,共3页
丹红合剂%脑缺血再灌注%含水量%含钙量
丹紅閤劑%腦缺血再灌註%含水量%含鈣量
단홍합제%뇌결혈재관주%함수량%함개량
Danhong mixture%Cerebral ischemia reperfusion%Moisture content%Calcium content
目的 研究丹红合剂对大鼠急性脑缺血再灌注损伤脑组织含水量及含钙量的影响.方法 选取健康SD大鼠60只,按照随机数字表随机分为6组,分别为假手术组、模型对照组,采用4血管法造脑缺血再灌注损伤模型,给药组分别给予不同剂量的丹红合剂和复方丹参注射液,观察丹红合剂对大鼠急性脑缺血再灌注损伤脑组织含水量及含钙量的影响.结果 丹红合剂高剂量组可降低大鼠急性脑缺血再灌注损伤脑组织含水量(75.84％)及含钙量(114.56 μg/g).丹红合剂中剂量组可降低大鼠急性脑缺血再灌注损伤脑组织含水量(80.13％)；降低大鼠急性脑缺血再灌注损伤脑组织含钙量(132.35 μg/g).丹红合剂低剂量组对大鼠急性脑缺血再灌注损伤脑组织含水量(73.94％)及含钙量(106.32.μg/g)有降低趋势,但差异无统计学意义.结论 丹红合剂能降低大鼠急性脑缺血再灌注损伤脑组织含水量及含钙量,提示其具有脑保护作用.
目的 研究丹紅閤劑對大鼠急性腦缺血再灌註損傷腦組織含水量及含鈣量的影響.方法 選取健康SD大鼠60隻,按照隨機數字錶隨機分為6組,分彆為假手術組、模型對照組,採用4血管法造腦缺血再灌註損傷模型,給藥組分彆給予不同劑量的丹紅閤劑和複方丹參註射液,觀察丹紅閤劑對大鼠急性腦缺血再灌註損傷腦組織含水量及含鈣量的影響.結果 丹紅閤劑高劑量組可降低大鼠急性腦缺血再灌註損傷腦組織含水量(75.84％)及含鈣量(114.56 μg/g).丹紅閤劑中劑量組可降低大鼠急性腦缺血再灌註損傷腦組織含水量(80.13％)；降低大鼠急性腦缺血再灌註損傷腦組織含鈣量(132.35 μg/g).丹紅閤劑低劑量組對大鼠急性腦缺血再灌註損傷腦組織含水量(73.94％)及含鈣量(106.32.μg/g)有降低趨勢,但差異無統計學意義.結論 丹紅閤劑能降低大鼠急性腦缺血再灌註損傷腦組織含水量及含鈣量,提示其具有腦保護作用.
목적 연구단홍합제대대서급성뇌결혈재관주손상뇌조직함수량급함개량적영향.방법 선취건강SD대서60지,안조수궤수자표수궤분위6조,분별위가수술조、모형대조조,채용4혈관법조뇌결혈재관주손상모형,급약조분별급여불동제량적단홍합제화복방단삼주사액,관찰단홍합제대대서급성뇌결혈재관주손상뇌조직함수량급함개량적영향.결과 단홍합제고제량조가강저대서급성뇌결혈재관주손상뇌조직함수량(75.84％)급함개량(114.56 μg/g).단홍합제중제량조가강저대서급성뇌결혈재관주손상뇌조직함수량(80.13％)；강저대서급성뇌결혈재관주손상뇌조직함개량(132.35 μg/g).단홍합제저제량조대대서급성뇌결혈재관주손상뇌조직함수량(73.94％)급함개량(106.32.μg/g)유강저추세,단차이무통계학의의.결론 단홍합제능강저대서급성뇌결혈재관주손상뇌조직함수량급함개량,제시기구유뇌보호작용.
Objective To Study the effects of Danhong mixture on water and calcium contents in brain tissue of rats with acute cerebral ischemia reperfusion injury.Methods 60 healthy SD rats were randomly divided into 6 groups,respectively,a sham operation group,a model control group,and 4 drug treatment groups.Models of cerebral ischemia reperfusion injury were established by 4 blood-vessel method,and administrated with different doses of Danhong mixture injection and compound salvia miltiorrhiza injection.Effects of Danhong mixture on water and calcium content in brain tissue of rats with acute cerebral ischemia and reperfusion injury were observed.Results Water and calcium content in brain tissue of rats with acute cerebral ischemia reperfusion injury were significantly decreased in Danhong mixture of high dose group (P＜0.01),(water was 75.84％ and calcium was 114.56 μg/g).Water and calcium content were also significantly decreased in Danhong mixture of medium dose group (P＜0.01),(water was 80.13％ and calcium was 132.35 μg/g)Water and calcium content showed decreasing tendency in Danhong mixture of low dose group,but without statistical significance,its numerical value was respectively 73.94％ and 106.32 μg/g.Conclusion Danhong mixture can reduce water and calcium content in brain tissue of rats with acute cerebral ischemia reperfusion injury,which indicated its neuroprotective effects.
