国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2013年
4期
326-328
,共3页
糖脂平颗粒%2型糖尿病%血糖%胰岛素样生长因子-Ⅰ
糖脂平顆粒%2型糖尿病%血糖%胰島素樣生長因子-Ⅰ
당지평과립%2형당뇨병%혈당%이도소양생장인자-Ⅰ
Tangzhiping granules%Type 2 diabetes mellitus%Blood glucose%IGF-Ⅰ
目的 探讨中药制剂糖脂平颗粒对2型糖尿病大鼠血清胰岛素样生长因子-Ⅰ (IGF-Ⅰ)的影响.方法 SPF级Wistar大鼠40只,雌雄各半,体重(200±20)g,基础饲料适应性饲养1周后,将大鼠按体重编号,以随机数字表法抽取8只为空白组,普通饲料喂养;其余大鼠均喂以高脂、高糖饲料.第6周,一次性左侧下腹部注射小剂量链脲佐菌素(STZ)诱导糖尿病模型.第8周,选择造模成功的30只大鼠称重并按体重编号,按照随机数字表法分为糖尿病模型组、糖脉康颗粒组、糖脂平颗粒组,分别予以生理盐水、糖脉康颗粒、糖脂平颗粒灌胃治疗.第12周处死大鼠,取血清检测各组大鼠血糖、血清IGF-Ⅰ.结果 ①与空白组比较,糖尿病模型组血糖(28.33±0.50) mmol/L升高,IGF-Ⅰ (3.40±0.83)pg/ml降低,说明造模成功.②与糖尿病模型组比较,糖脂平颗粒组、糖脉康颗粒组血糖[(15.06±0.39) mmol/L、(20.12±0.58) mmol/L]降低,IGF-Ⅰ[(9.39±2.91)pg/ml、(5.58±1.09) pg/ml]升高,两组比较差异有统计学意义.③与糖脉康颗粒组比较,糖脂平颗粒组的血糖降低、IGF-Ⅰ升高,差异均有统计学意义(P均＜0.05).结论 糖脂平颗粒可降低2型糖尿病模型大鼠血糖、升高IGF-Ⅰ,改善糖尿病的症状.
目的 探討中藥製劑糖脂平顆粒對2型糖尿病大鼠血清胰島素樣生長因子-Ⅰ (IGF-Ⅰ)的影響.方法 SPF級Wistar大鼠40隻,雌雄各半,體重(200±20)g,基礎飼料適應性飼養1週後,將大鼠按體重編號,以隨機數字錶法抽取8隻為空白組,普通飼料餵養;其餘大鼠均餵以高脂、高糖飼料.第6週,一次性左側下腹部註射小劑量鏈脲佐菌素(STZ)誘導糖尿病模型.第8週,選擇造模成功的30隻大鼠稱重併按體重編號,按照隨機數字錶法分為糖尿病模型組、糖脈康顆粒組、糖脂平顆粒組,分彆予以生理鹽水、糖脈康顆粒、糖脂平顆粒灌胃治療.第12週處死大鼠,取血清檢測各組大鼠血糖、血清IGF-Ⅰ.結果 ①與空白組比較,糖尿病模型組血糖(28.33±0.50) mmol/L升高,IGF-Ⅰ (3.40±0.83)pg/ml降低,說明造模成功.②與糖尿病模型組比較,糖脂平顆粒組、糖脈康顆粒組血糖[(15.06±0.39) mmol/L、(20.12±0.58) mmol/L]降低,IGF-Ⅰ[(9.39±2.91)pg/ml、(5.58±1.09) pg/ml]升高,兩組比較差異有統計學意義.③與糖脈康顆粒組比較,糖脂平顆粒組的血糖降低、IGF-Ⅰ升高,差異均有統計學意義(P均＜0.05).結論 糖脂平顆粒可降低2型糖尿病模型大鼠血糖、升高IGF-Ⅰ,改善糖尿病的癥狀.
목적 탐토중약제제당지평과립대2형당뇨병대서혈청이도소양생장인자-Ⅰ (IGF-Ⅰ)적영향.방법 SPF급Wistar대서40지,자웅각반,체중(200±20)g,기출사료괄응성사양1주후,장대서안체중편호,이수궤수자표법추취8지위공백조,보통사료위양;기여대서균위이고지、고당사료.제6주,일차성좌측하복부주사소제량련뇨좌균소(STZ)유도당뇨병모형.제8주,선택조모성공적30지대서칭중병안체중편호,안조수궤수자표법분위당뇨병모형조、당맥강과립조、당지평과립조,분별여이생리염수、당맥강과립、당지평과립관위치료.제12주처사대서,취혈청검측각조대서혈당、혈청IGF-Ⅰ.결과 ①여공백조비교,당뇨병모형조혈당(28.33±0.50) mmol/L승고,IGF-Ⅰ (3.40±0.83)pg/ml강저,설명조모성공.②여당뇨병모형조비교,당지평과립조、당맥강과립조혈당[(15.06±0.39) mmol/L、(20.12±0.58) mmol/L]강저,IGF-Ⅰ[(9.39±2.91)pg/ml、(5.58±1.09) pg/ml]승고,량조비교차이유통계학의의.③여당맥강과립조비교,당지평과립조적혈당강저、IGF-Ⅰ승고,차이균유통계학의의(P균＜0.05).결론 당지평과립가강저2형당뇨병모형대서혈당、승고IGF-Ⅰ,개선당뇨병적증상.
Objective To explore the effects of Tangzhiping granules on the blood glucose and IGF-Ⅰ in T2DM rats.Methods 40 SPF grade Wistar rats whose weight were about (200±20)g were selected as the subjects for this study,one half were male and another half were female.After be adapted to the normal food for 1 week,8 rats were selected randomly from all of rats following their weight as the blank group (ordinary feed).The remaining the others were fed with the high-fat and high-sugar food.The 6th week,the other rats would be undergo intraperitoneal injection once in left lower belly with 40 mg/kg streptozotocin (STZ),and enable them to become T2DM rats.The 8th week,we would select successful animal models 32 which were divided randomly into a modle group,a Tangmaikang (TMK) granules group,a Tangzhiping granules (TZP)group.The 12th week,we would execute all of rats and collect the blood serums which were tested for the blood glucose and IGF-Ⅰ.Results () Compared model group with blank group,the levels of the blood glucose of the model group increased to (28.33±0.50)mmol/L,while the IGF-Ⅰ decreased to (3.40 ± 0.83) pg/ml,which showed the model of type 2 diabetic rats was successfully set up.② The levels of the blood glucose of the Tangzhiping granules group and Tangmaikang granules group were lower than that of the model group to (15.06±0.39)mm ol/L,(20.12±0.58)mmol/L,but the levels of the IGF-Ⅰ were higher to (9.39±2.91)pg/ml,(5.58± 1.09)pg/ml,which implied that each group of pharmacological treatment had a good effect.③ The level of the blood glucose and IGF-Ⅰ of the Tangzhiping granules group was also significantly different from that of the Tangmaikang granule group,the therapeutic effect of Tangzhiping granules group was better than that of Tangmaikang granules group.Conclusion Tangzhiping granules can reduce the blood glucose of T2DM rats.And also can increase IGF-Ⅰ of T2DM rats.Tangzhiping granules can improve the various symptoms of diabetes mellitus at the same time.
