CAJ | 학술논문

目的考察溶液PH值、加热、光照和灭菌方法对中药汤剂安慰剂中着色剂的影响.方法用仪器测定颜色的Lab值,考察安慰剂生产配制过程中相关影响因素,如溶液PH值、加热、光照以及灭菌方法四个因素对胭脂红、日落黄60、亮蓝60、焦糖色4种色素溶液颜色的影响.结果溶液PH值对胭脂红和日落黄60溶液的颜色有影响,当胭脂红溶液的PH值调整为10时,溶液颜色发生明显变化,色差值为17.29,同样日落黄60溶液当PH值调整为10时,溶液颜色发生明显变化,色差值为27.29;酸化条件下对日落黄60和胭脂红溶液的颜色均无明显变化,PH的改变对亮蓝60和焦糖色溶液的颜色无明显影响,其色差值均小于1.5;短期的加热和光照对各色素溶液颜色无明显影响,加热和光照前后的溶液的色差值均小于1.5;60Co射线灭菌法对溶液颜色影响较大,胭脂红、日落黄60、亮蓝和焦糖色溶液在60Co射线照射后的容差值分别为12.43、22.45、37.53、19.22,均大于1.5；热压灭菌(121℃,20 min)不会改变溶液颜色,热压灭菌前后的溶液的色差值均小于1.5.结论上述着色剂适用于中药汤剂安慰剂的配制,建议在配制的最后环节加入,并避免采用60Co射线照射灭菌.
목적 고찰용액PH치、가열、광조화멸균방법대중약탕제안위제중착색제적영향.방법 용의기측정안색적Lab치,고찰안위제생산배제과정중상관영향인소,여용액PH치、가열、광조이급멸균방법사개인소대연지홍、일락황60、량람60、초당색4충색소용액안색적영향.결과 용액PH치대연지홍화일락황60용액적안색유영향,당연지홍용액적PH치조정위10시,용액안색발생명현변화,색차치위17.29,동양일락황60용액당PH치조정위10시,용액안색발생명현변화,색차치위27.29;산화조건하대일락황60화연지홍용액적안색균무명현변화,PH적개변대량람60화초당색용액적안색무명현영향,기색차치균소우1.5;단기적가열화광조대각색소용액안색무명현영향,가열화광조전후적용액적색차치균소우1.5;60Co사선멸균법대용액안색영향교대,연지홍、일락황60、량람화초당색용액재60Co사선조사후적용차치분별위12.43、22.45、37.53、19.22,균대우1.5；열압멸균(121℃,20 min)불회개변용액안색,열압멸균전후적용액적색차치균소우1.5.결론 상술착색제괄용우중약탕제안위제적배제,건의재배제적최후배절가입,병피면채용60Co사선조사멸균.
Objective To study the influencing factors of the colorants used in the placebo of herbal medicine.Methods The effect of pH value,temperature,and illumination and sterilization method on the coloring of the pigments like carmine,sunset yellow 60,brilliant blue 60 and caramel were investigated by determining the Lab value with the instrument.Results PH value of solution had effects on the coloring of carmine and sunset yellow 60,but no effects on the brilliant blue 60 and caramel.When pH values of the solutions were adjusted to 10,chromatic aberration values of carmine and sunset yellow 60 were 17.29 and 27.29,respectively; In the conditions of acidification,the color of carmine and sunset yellow 60 solutions were not changed much; short heating and illumination had no effects on all the four pigments,and all the chromatic aberration values were less than 1.5; 60Co-ray irradiation had great effects on the coloring,and the chromatic aberration values of carmine,sunset yellow 60,brilliant blue 60 and caramel solutions after 60Co-ray irradiation were 12.43,22.45,37.53 and 19.22,respectively; While autoclaving (121 ℃,20 min) would not change the color of solution,and all those chromatic aberration values were less than 1.5.Conclusion These colorants are suitable for the placebo preparation of Chinese medicine decoction,which is recommended to be added in the preparation of the final link.60Co-ray irradiation sterilization is forbidden.