中华急诊医学杂志
中華急診醫學雜誌
중화급진의학잡지
CHINESE JOURNAL OF EMERGENCY MEDICINE
2013年
5期
464-467
,共4页
李田华%苑连美%韩春芳%李志勇
李田華%苑連美%韓春芳%李誌勇
리전화%원련미%한춘방%리지용
肺炎支原体感染%凝血功能%儿童%病例对照
肺炎支原體感染%凝血功能%兒童%病例對照
폐염지원체감염%응혈공능%인동%병례대조
Mycoplasma pneumoniae infection%Coagulation function%Children%Case control
目的 探讨肺炎支原体感染对患儿凝血系统的影响及发病机制,为临床治疗儿童肺炎支原体感染提供依据.方法 前瞻性实验,采用病例对照研究方法,将2011年1月至2011年12月间来潍坊市人民医院住院治疗的36例肺炎支原体感染患儿作为实验组,其中肺炎支原体抗体(MP-IgM)为1∶80至1∶160为低滴度组,共17例；MP-IgM为1∶320至1∶1280为高滴度组,共19例；另外选取20例的同时期门诊健康查体儿童作为对照组.三组儿童体质量、年龄差异均无统计学意义(P＞0.05),具有可比性.分别测定三组儿童凝血常规六项及血浆D-二聚体定量等指标,采用SPSS 15.0软件进行统计学分析.结果 低滴度组和高滴度组儿童血浆纤维蛋白原定量(FIB)及D-二聚体定量均高于对照组儿童,差异均具有统计学意义(P＜0.05)；高滴度组儿童凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)均较对照组时间短,差异均具有统计学意义(P＜0.05).结论 肺炎支原体感染有潜在的可能激活外源性和内源性凝血系统,从而引起或促进血栓形成,重度感染容易导致患儿缺血性发作.
目的 探討肺炎支原體感染對患兒凝血繫統的影響及髮病機製,為臨床治療兒童肺炎支原體感染提供依據.方法 前瞻性實驗,採用病例對照研究方法,將2011年1月至2011年12月間來濰坊市人民醫院住院治療的36例肺炎支原體感染患兒作為實驗組,其中肺炎支原體抗體(MP-IgM)為1∶80至1∶160為低滴度組,共17例；MP-IgM為1∶320至1∶1280為高滴度組,共19例；另外選取20例的同時期門診健康查體兒童作為對照組.三組兒童體質量、年齡差異均無統計學意義(P＞0.05),具有可比性.分彆測定三組兒童凝血常規六項及血漿D-二聚體定量等指標,採用SPSS 15.0軟件進行統計學分析.結果 低滴度組和高滴度組兒童血漿纖維蛋白原定量(FIB)及D-二聚體定量均高于對照組兒童,差異均具有統計學意義(P＜0.05)；高滴度組兒童凝血酶原時間(PT)、活化部分凝血活酶時間(APTT)均較對照組時間短,差異均具有統計學意義(P＜0.05).結論 肺炎支原體感染有潛在的可能激活外源性和內源性凝血繫統,從而引起或促進血栓形成,重度感染容易導緻患兒缺血性髮作.
목적 탐토폐염지원체감염대환인응혈계통적영향급발병궤제,위림상치료인동폐염지원체감염제공의거.방법 전첨성실험,채용병례대조연구방법,장2011년1월지2011년12월간래유방시인민의원주원치료적36례폐염지원체감염환인작위실험조,기중폐염지원체항체(MP-IgM)위1∶80지1∶160위저적도조,공17례；MP-IgM위1∶320지1∶1280위고적도조,공19례；령외선취20례적동시기문진건강사체인동작위대조조.삼조인동체질량、년령차이균무통계학의의(P＞0.05),구유가비성.분별측정삼조인동응혈상규륙항급혈장D-이취체정량등지표,채용SPSS 15.0연건진행통계학분석.결과 저적도조화고적도조인동혈장섬유단백원정량(FIB)급D-이취체정량균고우대조조인동,차이균구유통계학의의(P＜0.05)；고적도조인동응혈매원시간(PT)、활화부분응혈활매시간(APTT)균교대조조시간단,차이균구유통계학의의(P＜0.05).결론 폐염지원체감염유잠재적가능격활외원성화내원성응혈계통,종이인기혹촉진혈전형성,중도감염용역도치환인결혈성발작.
Objective To study the effect of Mycoplasma pneumoniae infection on the coagulation system in children and to clarify its mechanism in order to guide the therapeutic strategy for Mycoplasma pneumoniae infection in clinical practice.Methods A prospective and case control study was carried out in 36 children with Mycoplasma pneumoniae infection in Weifang People ' s Hospital from January through December in 2011.The 36 patients were divided into two groups according to the MP-IgM plasma titers,namely low-titer group with MP-IgM 1 ∶ 80-1 ∶ 160 (n =17) and high-titer group with MP-IgM 1 ∶ 320-1 ∶1280 (n =19).The subjects of control group (n =20) were recruited from healthy children as they took routine physical examination during the same period.Six indexes related to the coagulation function as well as D-dimer in plasma were determined.All data were analyzed by using SPSS 15.0 software.Results The levels of fibrinogen (FIB) and D-dimer in the low-titer group and high-titer group were significantly higher than those in the control group (P ＜ 0.05).The prothrombin (PT) and activated partial thromboplastin time (APTT) in the high-titer group were significantly shorter than those in the control group respectively (P ＜ 0.05).Conclusions Mycoplasma pneumoniae infection in children gives rise to the potential for activating the extrinsic and intrinsic coagulation system,promoting thrombosis and in turn inducing ischemic stroke in serious cases.
