中华急诊医学杂志
中華急診醫學雜誌
중화급진의학잡지
CHINESE JOURNAL OF EMERGENCY MEDICINE
2013年
7期
712-715
,共4页
桂春%堵芳%农勤玲%连滨静%朱立光
桂春%堵芳%農勤玲%連濱靜%硃立光
계춘%도방%농근령%련빈정%주립광
不稳定型心绞痛%糖尿病%血管生成因子%血管内皮生长因子%血管形成蛋白
不穩定型心絞痛%糖尿病%血管生成因子%血管內皮生長因子%血管形成蛋白
불은정형심교통%당뇨병%혈관생성인자%혈관내피생장인자%혈관형성단백
Unstable angina pectoris%Diabetes%Angiogenic factors%Vascular endothelial growth factor%Angiopoietin
目的 检测不稳定型心绞痛患者血清中血管生成因子质量浓度的变化.方法 选择57例在广西医科大学第一附属医院住院并确诊为不稳定型心绞痛的患者为研究组,研究组又分为糖尿病亚组(23例)和非糖尿病亚组(34例).排除标准为病情复杂、伴有其他器官功能损害、外周血管病变、脑梗死和近期有感染的患者.对照组为在本院体检年龄相配的健康人,共36例.收集血清,然后使用蛋白芯片检测血清中血管内皮生长因子(VEGF)、血管形成蛋白-1(angiopoietin-1)、血管形成蛋白-2(angiopoietin-2)、血管生成素(angiogenin)、血管抑素(angiostatin)、碱性成纤维细胞生长因子(bFGF)和血小板衍生生长因子BB (PDGF-BB)质量浓度,使用SPSS 13.0软件对数据进行成组设计资料的t检验.结果 在不稳定型心绞痛患者血清中VEGF和angiopoietin-2质量浓度较正常对照组显著增高(均P＜0.01),而angiogenin、angiopoietin1、angiostatin、bFGF和PDGF-BB两组之间比较,差异无统计学意义.在糖尿病亚组和非糖尿病亚组之间比较,7个血管生成因子的血清浓度比较差异无统计学意义.结论 不稳定型心绞痛患者血清中VEGF和angiopoietin-2浓度明显增高,糖尿病并不影响这种变化.
目的 檢測不穩定型心絞痛患者血清中血管生成因子質量濃度的變化.方法 選擇57例在廣西醫科大學第一附屬醫院住院併確診為不穩定型心絞痛的患者為研究組,研究組又分為糖尿病亞組(23例)和非糖尿病亞組(34例).排除標準為病情複雜、伴有其他器官功能損害、外週血管病變、腦梗死和近期有感染的患者.對照組為在本院體檢年齡相配的健康人,共36例.收集血清,然後使用蛋白芯片檢測血清中血管內皮生長因子(VEGF)、血管形成蛋白-1(angiopoietin-1)、血管形成蛋白-2(angiopoietin-2)、血管生成素(angiogenin)、血管抑素(angiostatin)、堿性成纖維細胞生長因子(bFGF)和血小闆衍生生長因子BB (PDGF-BB)質量濃度,使用SPSS 13.0軟件對數據進行成組設計資料的t檢驗.結果 在不穩定型心絞痛患者血清中VEGF和angiopoietin-2質量濃度較正常對照組顯著增高(均P＜0.01),而angiogenin、angiopoietin1、angiostatin、bFGF和PDGF-BB兩組之間比較,差異無統計學意義.在糖尿病亞組和非糖尿病亞組之間比較,7箇血管生成因子的血清濃度比較差異無統計學意義.結論 不穩定型心絞痛患者血清中VEGF和angiopoietin-2濃度明顯增高,糖尿病併不影響這種變化.
목적 검측불은정형심교통환자혈청중혈관생성인자질량농도적변화.방법 선택57례재엄서의과대학제일부속의원주원병학진위불은정형심교통적환자위연구조,연구조우분위당뇨병아조(23례)화비당뇨병아조(34례).배제표준위병정복잡、반유기타기관공능손해、외주혈관병변、뇌경사화근기유감염적환자.대조조위재본원체검년령상배적건강인,공36례.수집혈청,연후사용단백심편검측혈청중혈관내피생장인자(VEGF)、혈관형성단백-1(angiopoietin-1)、혈관형성단백-2(angiopoietin-2)、혈관생성소(angiogenin)、혈관억소(angiostatin)、감성성섬유세포생장인자(bFGF)화혈소판연생생장인자BB (PDGF-BB)질량농도,사용SPSS 13.0연건대수거진행성조설계자료적t검험.결과 재불은정형심교통환자혈청중VEGF화angiopoietin-2질량농도교정상대조조현저증고(균P＜0.01),이angiogenin、angiopoietin1、angiostatin、bFGF화PDGF-BB량조지간비교,차이무통계학의의.재당뇨병아조화비당뇨병아조지간비교,7개혈관생성인자적혈청농도비교차이무통계학의의.결론 불은정형심교통환자혈청중VEGF화angiopoietin-2농도명현증고,당뇨병병불영향저충변화.
Objective To detect the changes in serum concentrations of angiogenic factors in patients with unstable angina pectoris.Methods A total of 57 patients with unstable angina pectoris were eligible for study and divided into diabetes group (n =23) and non-diabetes group (n =34).Exclusion criteria included complicated diseases,symptomatic peripheral vascular diseases,renal or liver diseases,cerebral embolism and evidence of ongoing infection.Another 36 age-matched healthy subjects from medical examination center were enrolled as control group.Serum samples were collected,and serum concentrations of vascular endothelial growth factor (VEGF),angiopoietin-1,angiopoietin-2,angiogenin,angiostatin,basic fibroblast growth factor (bFGF) and platelet-derived growth factor-BB (PDGF-BB) were measured by using cytokine array technology.The data were analyzed by independent-samples t test with the SPSS 13.0statistic software package.Results Compared with the control group,the serum concentrations of VEGF and angiopoietin-2 were significantly increased in patients with unstable angina pectoris (both P ＜ 0.01).Whereas,no significant differences in serum concentrations of angiogenin,angiopoietin-1,angiostatin,bFGF,and PDGF-BB were detected between control group and patient groups.There were no significant differences in serum concentrations of above all 7 biomarkers between diabetes group and non-diabetes group.Conclusions Serum concentrations of VEGF and angiopoietin-2 were increased in patients with unstable angina pectoris,and diabetes didn' t affect the increases in serum concentrations of VEGF and angiopoietin2 caused by unstable angina pectoris.
