CAJ | 학술논문

目的探讨分钟通气量恢复时间(minute ventilation recovery time,VERT)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者呼吸机撤离中的预测作用.方法前瞻性研究,入选2008年3月至2012年7月在本院呼吸重症监护病房中进行有创机械通气48 h以上的52例COPD患者,所有患者通过自主呼吸实验(spontaneous breathing trial,SBT)并准备撤机,在完成SBT后将呼吸机设置恢复到SBT前水平并连续观察25 min,得到VE RT值,即分钟通气量恢复到SBT前的基础值所用的时间.记录SBT前和SBT结束时的呼吸频率、潮气量、分钟通气量、浅快呼吸指数以及撤机前动脉血气分析指标.根据撤机结果将患者分为成功组40例和失败组12例.用t检验比较两组间VERT及其他指标的差异,用多因素Logistic回归分析探讨撤机结果的相关因素.用ROC曲线评价VERT预测撤机结果的敏感性和特异性.结果两组之间VERT和SBT结束时呼吸频率差异有统计学意义.多因素Logistic回归结果显示只有VERT与撤机结果存在相关性(b=0.282,P＜0.001).VERT的ROC曲线下面积0.957 (95％CI:0.907～1.008),VERT的cut-off值为10.5 min,预测撤机失败的敏感性为1.0,特异性为0.85.结论 VERT可以作为一个新的撤机指标预测COPD患者撤机结果.VERT测量方法简便,便于临床应用.
목적 탐토분종통기량회복시간(minute ventilation recovery time,VERT)재만성조새성폐질병(chronic obstructive pulmonary disease,COPD)환자호흡궤철리중적예측작용.방법 전첨성연구,입선2008년3월지2012년7월재본원호흡중증감호병방중진행유창궤계통기48 h이상적52례COPD환자,소유환자통과자주호흡실험(spontaneous breathing trial,SBT)병준비철궤,재완성SBT후장호흡궤설치회복도SBT전수평병련속관찰25 min,득도VE RT치,즉분종통기량회복도SBT전적기출치소용적시간.기록SBT전화SBT결속시적호흡빈솔、조기량、분종통기량、천쾌호흡지수이급철궤전동맥혈기분석지표.근거철궤결과장환자분위성공조40례화실패조12례.용t검험비교량조간VERT급기타지표적차이,용다인소Logistic회귀분석탐토철궤결과적상관인소.용ROC곡선평개VERT예측철궤결과적민감성화특이성.결과 량조지간VERT화SBT결속시호흡빈솔차이유통계학의의.다인소Logistic회귀결과현시지유VERT여철궤결과존재상관성(b=0.282,P＜0.001).VERT적ROC곡선하면적0.957 (95％CI:0.907～1.008),VERT적cut-off치위10.5 min,예측철궤실패적민감성위1.0,특이성위0.85.결론 VERT가이작위일개신적철궤지표예측COPD환자철궤결과.VERT측량방법간편,편우림상응용.
Objective To explore the value of minute ventilation recovery time (VERT) as a weaning predictor in mechanically ventilated patients with chronic obstructive pulmonary disease (COPD).Methods A prospective study was performed from March 2008 to July 2012.Fifty-two COPD patients under mechanical ventilation for more than 48 hours in our RICU tolerated a spontaneous breathing trial (SBT) and were ready for planned extubation.After SBT,these patients were placed back on their pre-SBT ventilator settings for up to 25 minutes,during which VERT was obtained.VERT was defined as the time for minute ventilation to return to baseline measured before SBT.Respiratory rate,tidal volume,minute ventilation and respiratory rate/tidal volume ratio were also obtained before SBT and just after SBT.Arterial blood gas data were measured and recorded before weaning.According to the weaning outcome,the patients were classified as successful group (40 cases) or failed group (12 cases).VERT and other quantitative variables were compared using t test.A multiple logistic regression was performed to explore possible factors associated with the weaning outcome.The sensitivity and specificity of VERT for predictive capacity in weaning were assessed using ROC cure.Results VERT and respiratory rate after SBT were significantly different between two groups.Multiple logistic regression revealed that VERT was the only predictor associated with weaning outcome (b =0.282,P ＜0.001).The area under ROC curve for VERT was 0.957 (95％ CI:O.907-1.008).With a cut-off value of 10.5 minutes,the sensitivity and specificity of VERT for predicting weaning failure were 1.0 and 0.85,respectively.Conclusions VERT may be a new predictor for extubation and determination of mechanical ventilation weaning in patients with COPD.VERT is a variable to be easily measured thereby being conveniently used in clinical practice.