CAJ | 학술논문

目的明确亚低温对室颤复苏后犬心功能及心律失常的影响.方法 12头比格犬随机(随机数字法)分成两组(n=6):常温复苏组(37.0±0.2)℃和亚低温组(34.0±0.2)℃,通过快速电刺激诱导室颤,7 min后行心肺复苏,动态观察比较两组犬的心率、左心室收缩力指数、室性心律失常、除颤能量、肾上腺素用量及复苏后1周心超变化.结果 ①与室颤前比较,两组犬左心室收缩力指数在复苏后均有不同程度降低(P＜0.05),但亚低温组下降幅度小于常温组,且心率低于常温组(141±19)次/minvs.(163±31)次/min,P＜0.05.②与常温组比较,亚低温组犬室性心律失常发生的次数明显减少(P＜0.05),但是除颤次数、肾上腺素用量差异无统计学意义(P＞0.05).③复苏后1周,两组犬的心超结果显示,心脏结构及射血分数均恢复正常.结论亚低温治疗可改善心脏骤停复苏后心肌收缩力,降低室性心律失常发生率.本研究结果提示,亚低温对复苏后心功能有一定的保护作用.
목적 명학아저온대실전복소후견심공능급심률실상적영향.방법 12두비격견수궤(수궤수자법)분성량조(n=6):상온복소조(37.0±0.2)℃화아저온조(34.0±0.2)℃,통과쾌속전자격유도실전,7 min후행심폐복소,동태관찰비교량조견적심솔、좌심실수축력지수、실성심률실상、제전능량、신상선소용량급복소후1주심초변화.결과 ①여실전전비교,량조견좌심실수축력지수재복소후균유불동정도강저(P＜0.05),단아저온조하강폭도소우상온조,차심솔저우상온조(141±19)차/minvs.(163±31)차/min,P＜0.05.②여상온조비교,아저온조견실성심률실상발생적차수명현감소(P＜0.05),단시제전차수、신상선소용량차이무통계학의의(P＞0.05).③복소후1주,량조견적심초결과현시,심장결구급사혈분수균회복정상.결론 아저온치료가개선심장취정복소후심기수축력,강저실성심률실상발생솔.본연구결과제시,아저온대복소후심공능유일정적보호작용.
Objective To investigate the effects of mild hypothennia on post-resuscitation myocardial function and arrhythmia incidence after ventricular fibrillation (VF) in canines.Methods A total of 12 beagles were randomly (random number) divided into 2 groups (n =6),normothermic resuscitation group (37.0 ± 0.2) ℃ and hypothermia group (34.0 ± 0.2) ℃.VF was induced by burst electrical stimulation on the epicardium.Cardiopulmonary resuscitation was initiated 7 min after VF.The heart rate (HR),index of left ventricular contractility (dPmx),ventricular arrhythmias,defibrillation energy,dosage of epinephrine during resuscitation were documented,and echocardiographic examinations were carried out a week after resuscitation for observing dynamically.Results The value of dPmx was lowered after successful defibrillation following prolonged VF in both normothermic and hypothermia groups (P ＜ 0.05).Compared with the normothermic resuscitation group,the hypothermia group had lower descend range of dPmx,lower HR (141 ± 19) bpm vs.(163 ± 31) bpm,P＜0.05; and lower incidence of ventricular arrhythmias (P ＜ 0.05).However,there were no significant differences in defibrillation energy and dosage of epinephrine between two groups (P ＞ 0.05).One week after resuscitation,the post-resuscitation cardiac structure and left ventricular ejection fraction resumed to nomal in both groups without difference between them.Conclusions Mild hypothermia could improve the left ventricular contractility and decrease the incidence of ventricular arrhythmias following resuscitation of cardiac arrest.The findings of this study indicated that mild hypothermia could exert protective effects on myocardial function following resuscitation in a canine model of cardiac arrest.