中华急诊医学杂志
中華急診醫學雜誌
중화급진의학잡지
CHINESE JOURNAL OF EMERGENCY MEDICINE
2014年
10期
1151-1154
,共4页
急性呼吸窘迫综合征%血管生成素-1%血管生成素-2%白介素-8
急性呼吸窘迫綜閤徵%血管生成素-1%血管生成素-2%白介素-8
급성호흡군박종합정%혈관생성소-1%혈관생성소-2%백개소-8
Acute respiratory distress syndrome%Angiopoietin-1%Angiopoietin-2%Interleukin-8
目的 探讨血清中血管生成素-1、2及白介素-8在评估ARDS中的临床价值.方法 筛选2012年1月至2013年7月湖南省人民医院急诊重症监护病房(EICU)的危重病患者283例,根据其病情是否发展为ARDS,分为非ARDS组(251例)和ARDS组(32例),并随访60 d,根据是否死亡,将非ARDS组和ARDS组再分为死亡组及存活组,采用ELISA测定其入院时Ang-1、2及IL-8的血清质量浓度,并对各组之间差异是否有统计学意义进行统计学及ROC曲线分析.结果 ARDS组患者EICU住院天数、机械通气时间、APACHEⅡ评分、血清血管生成素-2及IL-8水平显著高于非ARDS组患者,而Ang-1血清浓度显著低于非ARDS组患者.ARDS死亡组患者Ang-2、IL-8血清质量浓度显著高于非ARDS存活组及非ARDS死亡组,且ARDS死亡组患者血清Ang-2质量浓度显著高于ARDS存活组,其他各组之间比较差异无统计学意义.ROC曲线分析显示Ang-2具有最好的诊断效率,其诊断ARDS及预测ARDS死亡事件的曲线下面积分别为0.907和0.899,其灵敏度和特异性分别为0.969和0.725,0.907和0.882.结论 Ang-2是临床ARDS早期诊断及预后评估非常有价值的指标.
目的 探討血清中血管生成素-1、2及白介素-8在評估ARDS中的臨床價值.方法 篩選2012年1月至2013年7月湖南省人民醫院急診重癥鑑護病房(EICU)的危重病患者283例,根據其病情是否髮展為ARDS,分為非ARDS組(251例)和ARDS組(32例),併隨訪60 d,根據是否死亡,將非ARDS組和ARDS組再分為死亡組及存活組,採用ELISA測定其入院時Ang-1、2及IL-8的血清質量濃度,併對各組之間差異是否有統計學意義進行統計學及ROC麯線分析.結果 ARDS組患者EICU住院天數、機械通氣時間、APACHEⅡ評分、血清血管生成素-2及IL-8水平顯著高于非ARDS組患者,而Ang-1血清濃度顯著低于非ARDS組患者.ARDS死亡組患者Ang-2、IL-8血清質量濃度顯著高于非ARDS存活組及非ARDS死亡組,且ARDS死亡組患者血清Ang-2質量濃度顯著高于ARDS存活組,其他各組之間比較差異無統計學意義.ROC麯線分析顯示Ang-2具有最好的診斷效率,其診斷ARDS及預測ARDS死亡事件的麯線下麵積分彆為0.907和0.899,其靈敏度和特異性分彆為0.969和0.725,0.907和0.882.結論 Ang-2是臨床ARDS早期診斷及預後評估非常有價值的指標.
목적 탐토혈청중혈관생성소-1、2급백개소-8재평고ARDS중적림상개치.방법 사선2012년1월지2013년7월호남성인민의원급진중증감호병방(EICU)적위중병환자283례,근거기병정시부발전위ARDS,분위비ARDS조(251례)화ARDS조(32례),병수방60 d,근거시부사망,장비ARDS조화ARDS조재분위사망조급존활조,채용ELISA측정기입원시Ang-1、2급IL-8적혈청질량농도,병대각조지간차이시부유통계학의의진행통계학급ROC곡선분석.결과 ARDS조환자EICU주원천수、궤계통기시간、APACHEⅡ평분、혈청혈관생성소-2급IL-8수평현저고우비ARDS조환자,이Ang-1혈청농도현저저우비ARDS조환자.ARDS사망조환자Ang-2、IL-8혈청질량농도현저고우비ARDS존활조급비ARDS사망조,차ARDS사망조환자혈청Ang-2질량농도현저고우ARDS존활조,기타각조지간비교차이무통계학의의.ROC곡선분석현시Ang-2구유최호적진단효솔,기진단ARDS급예측ARDS사망사건적곡선하면적분별위0.907화0.899,기령민도화특이성분별위0.969화0.725,0.907화0.882.결론 Ang-2시림상ARDS조기진단급예후평고비상유개치적지표.
Objective To explore the clinical value of serum Ang-1,Ang-2 and IL-8 in ARDS prediction.Methods Totally 283 critically ill patients admitted in EICU of the Hunan Provincial People's Hospital from January 2012 to July 2013 were enrolled in this study and divided into the non-ARDS group (n =251) and ARDS group (n =32) depending on the development of ARDS.According to the occurrence of death in the following 60 days,the non-ARDS group and the ARDS group were further subdivided into the non-ARDS survival group,the non-ARDS death group,thc ARDS survival group and the ARDS death group.The differences in serum Ang-1,Ang-2 and IL-8 concentrations between these four groups measured by ELISA on admission were analyzed by statistical methods and ROC curve.Results The EICU stays,duration of mechanical ventilation,APACHE Ⅱ score、serum Ang-2 and IL-8 levels in the ARDS group were significantly higher than those in the non-ARDS group,while the Ang-1 level in the ARDS group was significantly lower than that in the non-ARDS group.The serum Ang-2 and IL-8 concentrations in the ARDS death group were significantly higher than those in the non-ARDS survival group and the non-ARDS death group,and the serum Ang-2 concentrations in the ARDS death group were also significantly higher than those in the ARDS survival group.Further ROC curve analysis showed that the area under the curve of Ang-2 for ARDS diagnosis and ARDS death prediction were 0.907 and 0.899 respectively and their diagnostic sensitivity and specificity were 0.969 and 0.725,0.907 and 0.882 respectively,illustrating that Ang-2 possess the best diagnostic efficiency.Conclusions Ang-2 functions as a valuable biomarker for early diagnosis and prognosis of ARDS.
