中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2010年
1期
4-8
,共5页
顾长江%张春辉%倪启超%何志贤
顧長江%張春輝%倪啟超%何誌賢
고장강%장춘휘%예계초%하지현
乳腺癌%骨转移%PSGL-1%PAR-1%免疫组化
乳腺癌%骨轉移%PSGL-1%PAR-1%免疫組化
유선암%골전이%PSGL-1%PAR-1%면역조화
Mammary cancer%Osseous metastasis%PSGL-1%PAR-1%Immunohistochemistry
目的 研究PSGL-1与PAR-1在乳腺癌骨转移中的表达及临床意义.方法 标本系本院48例术后发生骨转移的乳腺癌(A组)、50例术后未发生骨转移的乳腺癌(B组)和20例乳腺腺病(C组).应用免疫组化S-P染色法检测其中的PSGL-1与PAR-1的表达,分析其相关性和临床意义.结果 PGSL-1与PAR-1在A组中表达的阳性率分别为66.67%和62.5%,高于B组和C组(P<0.01).PGSL-1与PAR-1的高表达与乳腺癌组织学分级、腋窝淋巴结转移以及骨转移呈密切相关(P<0.05).PGSL-1与PAR-1的阳性表达与A组的年龄、绝经前后及肿瘤大小无关.结论 [1]乳腺癌PSGL-1与PAR-1的阳性表达提示肿瘤恶性程度高、易骨转移、预后差;[2]PSGL-1与PAR-1是两个独立的指标.
目的 研究PSGL-1與PAR-1在乳腺癌骨轉移中的錶達及臨床意義.方法 標本繫本院48例術後髮生骨轉移的乳腺癌(A組)、50例術後未髮生骨轉移的乳腺癌(B組)和20例乳腺腺病(C組).應用免疫組化S-P染色法檢測其中的PSGL-1與PAR-1的錶達,分析其相關性和臨床意義.結果 PGSL-1與PAR-1在A組中錶達的暘性率分彆為66.67%和62.5%,高于B組和C組(P<0.01).PGSL-1與PAR-1的高錶達與乳腺癌組織學分級、腋窩淋巴結轉移以及骨轉移呈密切相關(P<0.05).PGSL-1與PAR-1的暘性錶達與A組的年齡、絕經前後及腫瘤大小無關.結論 [1]乳腺癌PSGL-1與PAR-1的暘性錶達提示腫瘤噁性程度高、易骨轉移、預後差;[2]PSGL-1與PAR-1是兩箇獨立的指標.
목적 연구PSGL-1여PAR-1재유선암골전이중적표체급림상의의.방법 표본계본원48례술후발생골전이적유선암(A조)、50례술후미발생골전이적유선암(B조)화20례유선선병(C조).응용면역조화S-P염색법검측기중적PSGL-1여PAR-1적표체,분석기상관성화림상의의.결과 PGSL-1여PAR-1재A조중표체적양성솔분별위66.67%화62.5%,고우B조화C조(P<0.01).PGSL-1여PAR-1적고표체여유선암조직학분급、액와림파결전이이급골전이정밀절상관(P<0.05).PGSL-1여PAR-1적양성표체여A조적년령、절경전후급종류대소무관.결론 [1]유선암PSGL-1여PAR-1적양성표체제시종류악성정도고、역골전이、예후차;[2]PSGL-1여PAR-1시량개독립적지표.
Objective To study the PSGL-1 and PAR-1 expression in mammary cancer with osseous metastasis and its clinical significance. Methods To collect the records of postoperative cases of mammary lesions including 48 cases of breast cancer with osseous metastasis, 50 cases of breast cancer without osseous metastasis, and 20 cases of benign adenosis of breast. Specimens of all the cases were detected with S-P staining method for the examination of expression of PSGL-1 and PAR-1, and the clinical significance was analysed. Results The positive expression rates of PSGL-1 and PAR-1 detected in the postoperative cases of mammary cancer with osseous metastasis were 66.67 % and 62.5% respectively, which were higher than those in the postoperative cases of mammary cancer without osseous metastasis and benign adenosis of breast. The high expression of PSGL-1 and PAR-1 in breast cancer was a significantly related to the histological grade, axillary node metastasis and osseous metastasis. The high expression of PSGL-1 and PAR-1 in breast cancer was not related to the significant positive correlation between the expression of PSGL-1 and PAR-1 and that of HER-2 in mammary cancer. Conclusions (1)The high expression of PSGL-1 and PAR-1 in mammary cancer shows high malignancy and existence of osseous metastasis,and the prognosis is poor.(2) The PSGL-1 and PAR-1 are independent parameters.
