中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2012年
6期
379-383,387
,共6页
糖尿病%肾脏恶性肿瘤%队列研究%病例对照研究%Meta分析
糖尿病%腎髒噁性腫瘤%隊列研究%病例對照研究%Meta分析
당뇨병%신장악성종류%대렬연구%병례대조연구%Meta분석
Diabetes mellitus%Kidney cancer%Cohort studies%Case-control studies%Meta-analysis
目的 探讨糖尿病与肾脏恶性肿瘤发病风险的关系.方法 通过网络检索1990年1月至2011年10月PubMed数据库糖尿病患者发生肾脏恶性肿瘤风险性的相关队列研究和病例对照研究文献,按纳入和排除标准进行筛选、资料提取,采用RevMan 5.0软件完成meta分析.结果 共纳入14篇文献(8项队列研究和6项病例对照研究),共包括6,645,516例研究对象.Meta分析显示:糖尿病患者肾脏恶性肿瘤的发生率较对照组高,差异有统计学意义(OR=1.28,95％ CI 1.10～1.48,P＜0.05).分层研究发现,队列研究组中的糖尿病患者患肾脏恶性肿瘤的风险性较高(OR=1.32,95％ CI 1.14～1.53,P＜0.05),病例对照研究组中的糖尿病患者患肾脏恶性肿瘤的风险性并未增高(OR=1.21,95％CI 0.79～1.84,P＞0.05).结论 糖尿病与肾脏恶性肿瘤的发生有一定关联,但是否为肾脏恶性肿瘤发生的独立危险因素还需进一步研究.
目的 探討糖尿病與腎髒噁性腫瘤髮病風險的關繫.方法 通過網絡檢索1990年1月至2011年10月PubMed數據庫糖尿病患者髮生腎髒噁性腫瘤風險性的相關隊列研究和病例對照研究文獻,按納入和排除標準進行篩選、資料提取,採用RevMan 5.0軟件完成meta分析.結果 共納入14篇文獻(8項隊列研究和6項病例對照研究),共包括6,645,516例研究對象.Meta分析顯示:糖尿病患者腎髒噁性腫瘤的髮生率較對照組高,差異有統計學意義(OR=1.28,95％ CI 1.10～1.48,P＜0.05).分層研究髮現,隊列研究組中的糖尿病患者患腎髒噁性腫瘤的風險性較高(OR=1.32,95％ CI 1.14～1.53,P＜0.05),病例對照研究組中的糖尿病患者患腎髒噁性腫瘤的風險性併未增高(OR=1.21,95％CI 0.79～1.84,P＞0.05).結論 糖尿病與腎髒噁性腫瘤的髮生有一定關聯,但是否為腎髒噁性腫瘤髮生的獨立危險因素還需進一步研究.
목적 탐토당뇨병여신장악성종류발병풍험적관계.방법 통과망락검색1990년1월지2011년10월PubMed수거고당뇨병환자발생신장악성종류풍험성적상관대렬연구화병례대조연구문헌,안납입화배제표준진행사선、자료제취,채용RevMan 5.0연건완성meta분석.결과 공납입14편문헌(8항대렬연구화6항병례대조연구),공포괄6,645,516례연구대상.Meta분석현시:당뇨병환자신장악성종류적발생솔교대조조고,차이유통계학의의(OR=1.28,95％ CI 1.10～1.48,P＜0.05).분층연구발현,대렬연구조중적당뇨병환자환신장악성종류적풍험성교고(OR=1.32,95％ CI 1.14～1.53,P＜0.05),병례대조연구조중적당뇨병환자환신장악성종류적풍험성병미증고(OR=1.21,95％CI 0.79～1.84,P＞0.05).결론 당뇨병여신장악성종류적발생유일정관련,단시부위신장악성종류발생적독립위험인소환수진일보연구.
Objective To investigate the association between diabetes mellitus and risks of kidney cancer.Methods The cohort and case-control studies on the association between diabetes mellitus and risk of kidney cancer were analyzed by searching PubMed database within the time limit of Jan.1990 to Oct.2011.Data were selected according to the inclusion and exclusion criteria,and the meta-analysis was performed by using the Cochrane Collaboration's RevMan 5.0 software.Results A total of 14 studies(8 cohort studies and 6 case-control studies) involving 6,645,516 participants met the inclusion criteria.Meta analysis showed that patients with diabetes had a higher risk of kidney cancer compared with the control group without diabetes(OR =1.28,95％ CI 1.10 ～ 1.48,P ＜ 0.05).Stratification study showed that diabetes was associated with an increased risk of kidney cancer in cohort studies(OR =1.32,95％ CI 1.14-1.53,P ＜0.05),but this association was not found in casecontrol studies (OR =1.21,95 ％ CI 0.79-1.84,P ＞ 0.05).Conclusion This meta-analysis indicates a positive association between diabetes and risk of kidney cancer,however,future researches are needed to identify whether diabetes mellitus is an independent risk factor for kidney cancer.
