CAJ | 학술논문

目的探讨甲状腺结节内钙化类型对良恶性结节诊断的价值.方法回顾性分析了经手术病理证实的235例甲状腺结节患者的355个结节的术前超声图像.观察内容主要包括钙化的有无、大小及分布等.结果良性结节钙化发生率30.3％ (89/294),恶性结节发生率73.7％(45/61),2者差异有统计学意义(x2=24.3,P＜0.01).良性结节和恶性结节的微小钙化发生率分别为3.1％(9/294)和47.5％(29/61),2者差异有统计学意义(x2=99.1,P＜0.01)；良性结节和恶性结节粗大钙化发生率分别为27.2％(80/294)和26.2％(16/61),2者差异无统计学意义(x2=0.42,P＞0.05).结论甲状腺结节伴微小钙化是诊断甲状腺癌的一个特异性的指标,结节中的每一种钙化都有恶性的风险,不仅微小钙化,包括实性结节内部分布不规则的粗大钙化,恶性的危险性均明显增加.
목적 탐토갑상선결절내개화류형대량악성결절진단적개치.방법 회고성분석료경수술병리증실적235례갑상선결절환자적355개결절적술전초성도상.관찰내용주요포괄개화적유무、대소급분포등.결과 량성결절개화발생솔30.3％ (89/294),악성결절발생솔73.7％(45/61),2자차이유통계학의의(x2=24.3,P＜0.01).량성결절화악성결절적미소개화발생솔분별위3.1％(9/294)화47.5％(29/61),2자차이유통계학의의(x2=99.1,P＜0.01)；량성결절화악성결절조대개화발생솔분별위27.2％(80/294)화26.2％(16/61),2자차이무통계학의의(x2=0.42,P＞0.05).결론 갑상선결절반미소개화시진단갑상선암적일개특이성적지표,결절중적매일충개화도유악성적풍험,불부미소개화,포괄실성결절내부분포불규칙적조대개화,악성적위험성균명현증가.
Objective To investigate the significance of sonographic patterns of thyroid calcification in diagnosis of thyroid nodule.Methods 235 patients with 355 thyroid nodules were retrospectively analyzed.Nodule calcification size,distribution and pattern were observed.Results The incidence of calcification in benign and malignant nodules was 30.3％ (89/294)and 73.7％ (45/61) respectively.The difference had statistical significance(x2 =24.3,P ＜0.01).The rate of microcalcification in cancer was 47.5％ (29/61),higher than that in benign one 3.1％ (9/294)(x2 =99.1,P ＜ 0.01).Coarse calcification in benign nodules and malignant lesion was 27.2％ (80/294)and 26.2％ (16/61)respectively.The difference had no statistical significance(x2 =0.42,P ＞0.05).Conclusions Microcalcification of thyroid nodules is a specific index for thyroid carcinoma.Any type of sonographically detected calcification represents risk of malignancy.Not only microcalcification,these cases should raise the suspicion of malignancy in coarse calcification,especially involving a solitary nodule and irregular shape.