CAJ | 학술논문

目的探讨罗西维林联合坦索罗辛治疗经尿道前列腺电切术(transurethral resection of prostate,TURP)后膀胱过度活动症(overactive bladder,OAB)的临床疗效与安全性.方法临床采集93例TURP术后OAB,予罗西维林10 mg/次,3次/d及坦索罗辛0.2 mg/d,顿服,连续7～10 d.观察患者治疗前后主观指标OAB评分(OABSS)、国际前列腺症状评分(IpSS)和生活质量评分(QOL)及客观指标24 h排尿次数、尿急次数、尿失禁次数、夜尿次数、每次排尿量的变化,并结合药物副反应发生率,评估治疗后患者OAB症状的改善情况及安全性.结果 93例平均服药时间为(5±3)d,治疗后OABSS评分平均降低8.12分(P＜0.01),且均≤4分,IPSS评分平均降低16.69分(P＜0.01),QOL评分平均降低2.18分(P＜0.01).治疗后24h排尿次数、尿急次数、尿失禁次数、夜尿次数、每次排尿量较治疗前均有显著变化,差异有统计学意义(P＜0.05).药物副反应发生率为2.1％(2例出现口渴症状).结论罗西维林联合坦索罗辛治疗TURP术后OAB疗效显著,安全可靠.
목적 탐토라서유림연합탄색라신치료경뇨도전렬선전절술(transurethral resection of prostate,TURP)후방광과도활동증(overactive bladder,OAB)적림상료효여안전성.방법 림상채집93례TURP술후OAB,여라서유림10 mg/차,3차/d급탄색라신0.2 mg/d,돈복,련속7～10 d.관찰환자치료전후주관지표OAB평분(OABSS)、국제전렬선증상평분(IpSS)화생활질량평분(QOL)급객관지표24 h배뇨차수、뇨급차수、뇨실금차수、야뇨차수、매차배뇨량적변화,병결합약물부반응발생솔,평고치료후환자OAB증상적개선정황급안전성.결과 93례평균복약시간위(5±3)d,치료후OABSS평분평균강저8.12분(P＜0.01),차균≤4분,IPSS평분평균강저16.69분(P＜0.01),QOL평분평균강저2.18분(P＜0.01).치료후24h배뇨차수、뇨급차수、뇨실금차수、야뇨차수、매차배뇨량교치료전균유현저변화,차이유통계학의의(P＜0.05).약물부반응발생솔위2.1％(2례출현구갈증상).결론 라서유림연합탄색라신치료TURP술후OAB료효현저,안전가고.
Objective To study the efficacy and safety of rociverine combined with tamsulosin in treatment of overactive bladder after transurethral resection of prostate (TURP).Methods 93 cases of overactive bladder patients who received TURP were collected.They were given rociverine tablets 10 mg 3 times a day and tamsulosin 0.2 mg once a day for 7 to 10 days.The efficacy and safety of treatment were assessed by changes before and after treatment in subjective indicators of overactive bladder syndrome score(OABSS),the international prostate symptom score(IPSS) and quality of life score(QOL) and objective indicators including daily frequency of micturition,urgency,urgency incontinence,nocturia,voiding volumes,combining with the adverse drug reaction incidence.Results The average treating time for the 93 cases was (5 ± 3) days.The average score of OABSS reduced 8.12(P ＜0.01,and each score≤ 4).The average score of IPSS reduced 16.69(P ＜0.01).The average score of QOL reduced 2.18 (P ＜ 0.01).There was statistical difference in objective indicators of patients between before and after treatment(P ＜ O.05).The adverse drug reaction incidence was 2.1％ (2 cases with thirsty symptom).Conclusion Rociverine tablets combined with tamsulosin in treatment of patients with overactive bladder after TURP are effective and safe.