中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2013年
5期
424-425
,共2页
黄东航%游振辉%李华水%张爱龙%王沆%邱丽贞%林强
黃東航%遊振輝%李華水%張愛龍%王沆%邱麗貞%林彊
황동항%유진휘%리화수%장애룡%왕항%구려정%림강
甲状腺滤泡性肿瘤%免疫组织化学%基因表达
甲狀腺濾泡性腫瘤%免疫組織化學%基因錶達
갑상선려포성종류%면역조직화학%기인표체
Thyroid neoplasms%Immunohistochemistry%Gene expression
目的 探讨Galectin-3在甲状腺滤泡性肿瘤中的表达,及其鉴别诊断良、恶性甲状腺滤泡性肿瘤的价值.方法 对120例甲状腺滤泡性癌及80例甲状腺滤泡性腺瘤应用免疫组织化学方法检测Galectin-3的表达.结果 Galectin-3表达阳性率在甲状腺滤泡性癌为84％,在甲状腺滤泡性腺瘤为19％(P＜0.01).Galectin-3表达强阳性者,在甲状腺滤泡性癌占40％,而在甲状腺滤泡性腺瘤,无一例强阳性.结论 Galectin-3表达可作为鉴别甲状腺良、恶性滤泡性肿瘤的重要参考指标.
目的 探討Galectin-3在甲狀腺濾泡性腫瘤中的錶達,及其鑒彆診斷良、噁性甲狀腺濾泡性腫瘤的價值.方法 對120例甲狀腺濾泡性癌及80例甲狀腺濾泡性腺瘤應用免疫組織化學方法檢測Galectin-3的錶達.結果 Galectin-3錶達暘性率在甲狀腺濾泡性癌為84％,在甲狀腺濾泡性腺瘤為19％(P＜0.01).Galectin-3錶達彊暘性者,在甲狀腺濾泡性癌佔40％,而在甲狀腺濾泡性腺瘤,無一例彊暘性.結論 Galectin-3錶達可作為鑒彆甲狀腺良、噁性濾泡性腫瘤的重要參攷指標.
목적 탐토Galectin-3재갑상선려포성종류중적표체,급기감별진단량、악성갑상선려포성종류적개치.방법 대120례갑상선려포성암급80례갑상선려포성선류응용면역조직화학방법검측Galectin-3적표체.결과 Galectin-3표체양성솔재갑상선려포성암위84％,재갑상선려포성선류위19％(P＜0.01).Galectin-3표체강양성자,재갑상선려포성암점40％,이재갑상선려포성선류,무일례강양성.결론 Galectin-3표체가작위감별갑상선량、악성려포성종류적중요삼고지표.
Objective To analyze the expression of Galectin-3 in thyroid follicular tumors and its clinical significance in differential diagnosis between benign and malignant thyroid follicular tumor.Methods The expression of Galectin-3 in 120 cases of thyroid follicular carcinoma and 80 cases of thyroid follicular adenoma was detected by immunohistochemical technique.Results The expression rate of Galectin-3 in thyroid follicular carcinoma was significantly higher than that in follicular adenoma(84％ vs 19％,P ＜ 0.01).Strong positive expression of Galectin-3 was found in 40％ cases of thyroid follicular carcinoma and no case of thyroid follicular adenoma.Conclusions The expression of Galectin-3 can be regarded as an important parameter for differential diagnosis between benign and malignant thyroid follicular tumor.
