中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2014年
3期
189-192
,共4页
梅劼%王海莲%刘运强%宋文忠%梁亚明%甘露%尹诗%董先觉%邓绍平
梅劼%王海蓮%劉運彊%宋文忠%樑亞明%甘露%尹詩%董先覺%鄧紹平
매할%왕해련%류운강%송문충%량아명%감로%윤시%동선각%산소평
妊娠糖耐量异常%基因单核苷酸多态性%CDKN2A/2B
妊娠糖耐量異常%基因單覈苷痠多態性%CDKN2A/2B
임신당내량이상%기인단핵감산다태성%CDKN2A/2B
Gestational glucose intolerance%Single nucleotide polymorphism%CDKN2A/2B
目的 研究CDKN2A/2B基因rs2383208的单核苷酸多态性与中国西南地区汉族妊娠期妇女糖耐量的相关性.方法 选取中国西南地区汉族妊娠期妇女作为研究对象,其中糖耐量正常组495例(59.64％),糖耐量异常组335例(40.36％);糖耐量异常组包括空腹血糖异常及糖耐量受损组279例(33.62％)和妊娠糖尿病组56例(6.74％).提取全血基因组DNA,采用飞行质谱法检测CDKN2A/2B基因rs2383208单核苷酸位点多态性.结果 CDKN2A/2B基因rs2383208的AA、AG、GG 3种基因型在所检测妇女的糖耐量正常组与糖耐量异常组间分布差异无统计学意义(P＞0.05).结论 在西南地区妊娠妇女中,未发现CDKN2A/2B基因rs2383208 A/G多态性与妊娠期糖耐量异常具有明显相关性.
目的 研究CDKN2A/2B基因rs2383208的單覈苷痠多態性與中國西南地區漢族妊娠期婦女糖耐量的相關性.方法 選取中國西南地區漢族妊娠期婦女作為研究對象,其中糖耐量正常組495例(59.64％),糖耐量異常組335例(40.36％);糖耐量異常組包括空腹血糖異常及糖耐量受損組279例(33.62％)和妊娠糖尿病組56例(6.74％).提取全血基因組DNA,採用飛行質譜法檢測CDKN2A/2B基因rs2383208單覈苷痠位點多態性.結果 CDKN2A/2B基因rs2383208的AA、AG、GG 3種基因型在所檢測婦女的糖耐量正常組與糖耐量異常組間分佈差異無統計學意義(P＞0.05).結論 在西南地區妊娠婦女中,未髮現CDKN2A/2B基因rs2383208 A/G多態性與妊娠期糖耐量異常具有明顯相關性.
목적 연구CDKN2A/2B기인rs2383208적단핵감산다태성여중국서남지구한족임신기부녀당내량적상관성.방법 선취중국서남지구한족임신기부녀작위연구대상,기중당내량정상조495례(59.64％),당내량이상조335례(40.36％);당내량이상조포괄공복혈당이상급당내량수손조279례(33.62％)화임신당뇨병조56례(6.74％).제취전혈기인조DNA,채용비행질보법검측CDKN2A/2B기인rs2383208단핵감산위점다태성.결과 CDKN2A/2B기인rs2383208적AA、AG、GG 3충기인형재소검측부녀적당내량정상조여당내량이상조간분포차이무통계학의의(P＞0.05).결론 재서남지구임신부녀중,미발현CDKN2A/2B기인rs2383208 A/G다태성여임신기당내량이상구유명현상관성.
Objective To investigate the association between CDKN2A/2B rs2383208 and the gestational glucose intolerance in pregnant southwest Han Chinese women.Methods The study recruited 495 (59.64 ％) women with normal glucose tolerance pregnant(NGT) and 335 (40.36％) women with glucose intolerance.The glucose intolerance group included 279(33.62％)women with impaired fasting glucose(IFG) or impaired glucose tolerance (IGT),and 56 (6.74％) women with gestational diabetes (GDM)..The genotype of CDKN2A/2B rs2383208 in these women was determined and analyzed.Results No significant association was observed between CDKN2A/2B rs2383208 and the gestational glucose intolerance in the studied women(P ＞ 0.05).Conclusions The CDKN2A/2B rs2383208 gene may not be related to the gestational glucose intolerance in southwest Han Chinese women.
