中华实用儿科临床杂志
中華實用兒科臨床雜誌
중화실용인과림상잡지
Journal of Applied Clinical Pediatrics
2014年
7期
483-486
,共4页
胃肠动力%促胃肠动力药物%胃肠动力障碍性疾病
胃腸動力%促胃腸動力藥物%胃腸動力障礙性疾病
위장동력%촉위장동력약물%위장동력장애성질병
Gastrointestinal motility%Prokinetics%Gastrointestinal motility disorders
胃肠动力障碍性疾病在儿童中的发病率高,但可供选择的促动力剂种类稀少,使临床治疗效果欠佳,长期有效缓解率较低,因此,新型促动力剂的研制一直是儿童胃肠病学研究的重点.目前供成人使用的促动力剂主要有中枢或外周多巴胺受体拮抗剂、血清素激动剂及胃动素受体激动剂,而供儿科可选择的药物种类更少.现主要介绍目前几类促动力剂在成人及儿童中的研究现状,并对未来促动力剂的发展方向作出展望.
胃腸動力障礙性疾病在兒童中的髮病率高,但可供選擇的促動力劑種類稀少,使臨床治療效果欠佳,長期有效緩解率較低,因此,新型促動力劑的研製一直是兒童胃腸病學研究的重點.目前供成人使用的促動力劑主要有中樞或外週多巴胺受體拮抗劑、血清素激動劑及胃動素受體激動劑,而供兒科可選擇的藥物種類更少.現主要介紹目前幾類促動力劑在成人及兒童中的研究現狀,併對未來促動力劑的髮展方嚮作齣展望.
위장동력장애성질병재인동중적발병솔고,단가공선택적촉동력제충류희소,사림상치료효과흠가,장기유효완해솔교저,인차,신형촉동력제적연제일직시인동위장병학연구적중점.목전공성인사용적촉동력제주요유중추혹외주다파알수체길항제、혈청소격동제급위동소수체격동제,이공인과가선택적약물충류경소.현주요개소목전궤류촉동력제재성인급인동중적연구현상,병대미래촉동력제적발전방향작출전망.
Gastrointestinal motility disorders are in high incidence in children.Due to moderate prokinetic effects,poor symptomatic responses and the presence of adverse effects,there is a clear need for new classes of prokinetics.Currently available drug classes in adult include antidopami-nergic agents,serotonergic agents,and motilin-receptor while there are less available drug classes in children.The aim of the present article is to review and address the present use of promotility drugs in the treatment of different gastrointestinal motor disorders,as well as the potential for future developments.
