CAJ | 학술논문

目的调查南京地区经胃镜检查儿童的幽门螺杆菌(Hp)感染情况.方法选择南京医科大学附属南京儿童医院2001年1月至2010年12月行胃镜检查儿童2 990例,进行胃窦黏膜标本快速Hp尿素酶试验.结果 10年间2 990例患儿行胃镜检查,其中男性患儿1 718例,Hp感染检出率为53.8％(924/1 718例);女性患儿1 272例,Hp感染检出率为52.4％(667/1 272例),男女之间Hp感染检出率比较差异无统计学意义(x2＝0.532,P ＞0.05).2001年1月至2005年12月共检测611例儿童,Hp感染检出率为66.9％(409/611例),2006年1月至2010年12月共检测2 379例儿童,Hp感染检出率为49.7％(1 182/2 379例),差异有统计学意义(x2＝58.13,P=0.01).0～6岁359例,Hp感染检出率为49.6％(178/359例);＞6～9岁930例,Hp感染检出率为48.1％(447/930例);＞9～12岁1 089例,Hp感染检出率为55.2％(601/1 089例);＞12岁612例,Hp感染检出率为60.0％(365/612例),4组间Hp感染检出率比较差异有统计学意义(x2 =23.66,P＜0.01).消化道出血、上消化道症状、不明原因贫血及不明原因的脐周痛Hp感染检出率比较差异无统计学意义(x2=5.04,P ＞0.05).结节性胃炎Hp感染检出率高达61.4％,高于慢性浅表性胃炎Hp感染检出率(50.6％),差异有统计学意义(x2＝7.42,P＜0.01);过敏性紫癜Hp感染检出率为46.2％,高于胃镜正常儿童Hp感染检出率(15.9％),差异有统计学意义(x2=10.19,P＜0.01).结论南京地区胃镜检查儿童Hp感染率有逐年下降趋势;6岁后Hp阳性率随年龄而稳定增长;Hp感染在儿童结节性胃炎和过敏性紫癜的发生中起一定作用.
목적 조사남경지구경위경검사인동적유문라간균(Hp)감염정황.방법 선택남경의과대학부속남경인동의원2001년1월지2010년12월행위경검사인동2 990례,진행위두점막표본쾌속Hp뇨소매시험.결과 10년간2 990례환인행위경검사,기중남성환인1 718례,Hp감염검출솔위53.8％(924/1 718례);녀성환인1 272례,Hp감염검출솔위52.4％(667/1 272례),남녀지간Hp감염검출솔비교차이무통계학의의(x2＝0.532,P ＞0.05).2001년1월지2005년12월공검측611례인동,Hp감염검출솔위66.9％(409/611례),2006년1월지2010년12월공검측2 379례인동,Hp감염검출솔위49.7％(1 182/2 379례),차이유통계학의의(x2＝58.13,P=0.01).0～6세359례,Hp감염검출솔위49.6％(178/359례);＞6～9세930례,Hp감염검출솔위48.1％(447/930례);＞9～12세1 089례,Hp감염검출솔위55.2％(601/1 089례);＞12세612례,Hp감염검출솔위60.0％(365/612례),4조간Hp감염검출솔비교차이유통계학의의(x2 =23.66,P＜0.01).소화도출혈、상소화도증상、불명원인빈혈급불명원인적제주통Hp감염검출솔비교차이무통계학의의(x2=5.04,P ＞0.05).결절성위염Hp감염검출솔고체61.4％,고우만성천표성위염Hp감염검출솔(50.6％),차이유통계학의의(x2＝7.42,P＜0.01);과민성자전Hp감염검출솔위46.2％,고우위경정상인동Hp감염검출솔(15.9％),차이유통계학의의(x2=10.19,P＜0.01).결론 남경지구위경검사인동Hp감염솔유축년하강추세;6세후Hp양성솔수년령이은정증장;Hp감염재인동결절성위염화과민성자전적발생중기일정작용.
Objective To investigate Helicobacter pyloric (Hp) infection in children who underwent gastroscopy in Nanjing area.Methods From Jan.2001 to Dec.2010,2 990 pediatric patients with gastrointestinal symptoms who underwent endoscopy and Hp rapid urease test of gastric mucosa specimens.Results There were 2 990 patients who underwent gastroscopy during the 10 years including 1 718 cases of male and 1 272 cases of female.The rate of Hp infection was 53.8％ (924/1 718 cases) and 52.4％ (667/1 272 cases) in male and female,respectively.There was no significant difference (x2 ＝ 0.532,P ＞ 0.05).From Jan.2001 to Dec.2005,611 patients were tested and the rate of Hp infection was 66.9％ (409/611 cases).From Jan.2006 to Dec.2010,2 379 patients were tested and the rate of Hp infection was 49.7％.There was significant difference(x2 =58.13,P =0.01) between the 2 groups.The rate of Hp infection were 49.6％,48.1％,55.2％,60.0％ in 0-6 years group,＞6-9 years group,＞9-12 years group,and ＞ 12 years group,respectively.There was significant difference among the 4 different age groups (x2 =23.66,P ＜ 0.01).The rate of Hp infection in nodular gastritis(61.4％) was higher than that in chronic superficial gastritis (50.6％).There was significant difference between the 2 groups (x2 ＝ 7.42,P ＜ 0.01).The rate of Hp infection in allergic purpura (46.2％) was higher compared with the children with normal gastroscopy results (15.9％).There was significant difference between the 2 groups (x2 =10.19,P ＜ 0.01).Conclusions There is gradually downward trend by year in the rate of Hp infection of children who underwent gastroscopy in Nanjing area by year.The rate of Hp infection is increasing with the age after the age of 6 years.Hp infection may play a role in the nodular gastritis and allergic purpura.