CAJ | 학술논문

目的探讨福建地区女童特发性中枢性性早熟(ICPP)发生的主要危险因素.方法采用病例-对照研究,选择2011年10月至2013年10月在福建省福州儿童医院内分泌科确诊为ICPP的女童566例以及来源于体检中心的健康女童547例作为研究对象,对儿童的饮食情况、行为方面、父母及家庭情况进行问卷调查,并对相关因素进行Logistic回归分析.结果单因素分析发现23个变量差异有统计学意义.Logistic回归分析,最终进入模型的变量:母亲初潮年龄＞13岁(B=-1.28,SE =0.17,Wald=59.82,OR=0.278,95％CI:0.201 ～0.384,P＜0.001)、摄入有机水果(B=-1.15,SE=0.36,Wald=10.51,OR=0.316,95％ CI:0.157～0.634,P=0.001)、每天运动时间(B=-0.50,SE=0.11,Wald=19.74,OR=0.609,95％ CI:0.490 ～0.758,P＜0.001)、普通蔬菜(B=0.24,SE=0.08,Wald=9.79,OR=1.275,95％ CI:1.095 ～1.485,P=0.002)、普通家畜(B =0.31,SE =0.07,Wald=22.35,OR=1.364,95％ CI:1.199 ～1.551,P＜0.001)、体质量指数(B =0.47,SE=0.08,Wald=33.74,OR=1.599,95％ CI:1.365 ～1.874,P＜0.001)、父母月收入总和(B=0.51,SE =0.12,Wald=17.89,OR=1.671,95％CI:1.317 ～2.120,P＜0.001)、自觉课业负担沉重(B=0.60,SE=0.25,Wald=5.87,OR=1.818,95％ CI:1.121～2.948,P=0.015)、各种方便食品(快食面)(B=1.10,SE =0.45,Wald=5.96,OR=2.990,95％ CI:1.241～7.203,P=0.015)、服用营养品(B=1.32,SE=0.30,Wald=18.93,OR=3.736,95％ CI:2.063～6.765,P＜0.001)、经常使用成人洗漱护肤品(B=1.67,SE=0.25,Wald =44.5,OR=5.284,95％CI:3.240～8.618,P＜0.001).其中母亲初潮年龄＞13岁、摄入有机水果、每天运动时间长是ICPP的保护因素,其他均为ICPP的危险因素.结论福建地区女童ICPP相关因素众多,其发病与母亲初潮年龄、饮食行为习惯、体质量指数、家庭经济状况及学习压力相关.
목적 탐토복건지구녀동특발성중추성성조숙(ICPP)발생적주요위험인소.방법 채용병례-대조연구,선택2011년10월지2013년10월재복건성복주인동의원내분비과학진위ICPP적녀동566례이급래원우체검중심적건강녀동547례작위연구대상,대인동적음식정황、행위방면、부모급가정정황진행문권조사,병대상관인소진행Logistic회귀분석.결과 단인소분석발현23개변량차이유통계학의의.Logistic회귀분석,최종진입모형적변량:모친초조년령＞13세(B=-1.28,SE =0.17,Wald=59.82,OR=0.278,95％CI:0.201 ～0.384,P＜0.001)、섭입유궤수과(B=-1.15,SE=0.36,Wald=10.51,OR=0.316,95％ CI:0.157～0.634,P=0.001)、매천운동시간(B=-0.50,SE=0.11,Wald=19.74,OR=0.609,95％ CI:0.490 ～0.758,P＜0.001)、보통소채(B=0.24,SE=0.08,Wald=9.79,OR=1.275,95％ CI:1.095 ～1.485,P=0.002)、보통가축(B =0.31,SE =0.07,Wald=22.35,OR=1.364,95％ CI:1.199 ～1.551,P＜0.001)、체질량지수(B =0.47,SE=0.08,Wald=33.74,OR=1.599,95％ CI:1.365 ～1.874,P＜0.001)、부모월수입총화(B=0.51,SE =0.12,Wald=17.89,OR=1.671,95％CI:1.317 ～2.120,P＜0.001)、자각과업부담침중(B=0.60,SE=0.25,Wald=5.87,OR=1.818,95％ CI:1.121～2.948,P=0.015)、각충방편식품(쾌식면)(B=1.10,SE =0.45,Wald=5.96,OR=2.990,95％ CI:1.241～7.203,P=0.015)、복용영양품(B=1.32,SE=0.30,Wald=18.93,OR=3.736,95％ CI:2.063～6.765,P＜0.001)、경상사용성인세수호부품(B=1.67,SE=0.25,Wald =44.5,OR=5.284,95％CI:3.240～8.618,P＜0.001).기중모친초조년령＞13세、섭입유궤수과、매천운동시간장시ICPP적보호인소,기타균위ICPP적위험인소.결론 복건지구녀동ICPP상관인소음다,기발병여모친초조년령、음식행위습관、체질량지수、가정경제상황급학습압력상관.
Objective To investigate the potential risk factors for idiopathic central precocious puberty(ICPP) in girls of Fujian province.Methods Case-control study was conducted in 566 girls who were diagnosed with ICPP at endocrinology department and 547 healthy girls for routine physical examination at Fuzhou Children's Hospital of Fujian from Oct.2011 to Oct.2013.Parents were asked to fulfill the questionnaires including children's diets,behaviors,parents and family conditions,and Logistic regression analysis was conducted for detecting risk factors.Results Chi square test showed that 23 variables had significantly statistical difference.Logistic regression analysis indicated that some variables were included in the final model:mother's age at menarche older than 13 years(B =-1.28,SE =0.17,Wald =59.82,OR =0.278,95 ％ CI:0.201-0.384,P ＜ 0.001),organic fruits intake (B =-1.15,SE =0.36,Wald =10.51,OR =0.316,95％ CI:0.157-0.634,P =0.001),daily exercise time(B =-0.50,SE =0.11,Wald =19.74,OR =0.609,95％ CI:0.490-0.758,P ＜ 0.001),ordinary vegetables intake (B =0.24,SE =0.08,Wald =9.79,OR =1.275,95 ％ CI:1.095-1.485,P =0.002),general livestock intake (B =0.31,SE =0.07,Wald =22.35,OR =1.364,95 ％ CI:1.199-1.551,P ＜ 0.001),body mass index (B =0.47,SE =0.08,Wald =33.74,OR =1.599,95 ％ CI:1.365-1.874,P ＜ 0.001),income of parents (B =0.51,SE =0.12,Wald =17.89,OR =1.671,95 ％ CI:1.317-2.120,P ＜ 0.001),heavy study burden (B =0.60,SE =0.25,Wald =5.87,OR =1.818,95 ％ CI:1.121-2.948,P =0.015),instant food intake (B =1.10,SE =0.45,Wald =5.96,OR =2.990,95 ％ CI:1.241-7.203,P =0.015),nourishment intake (B =1.32,SE =0.30,Wald =18.93,OR =3.736,95 ％ CI:2.063-6.765,P ＜ 0.001),and adult cosmetics use (B =1.67,SE =0.25,Wald =44.5,OR =5.284,95 ％ CI:3.240-8.618,P ＜ 0.001).Among the varia bles,factors like mother's age at menarche older than 13 years,more organic fruit intake and long-time exercise were found to be the protective factors from ICPP,and others were risk factors for ICPP.Conclusions There were many factors related to ICPP in girls of Fujian province,such as mother's age at menarche,diet and behaviors,body mass index,parental income,and heavy study burden.