CAJ | 학술논문

目的探讨血清内脂素(visfatin)和促酰化蛋白(ASP)与单纯性肥胖症儿童发病的关系及其对肥胖症防治的意义.方法研究对象共86例,男57例,女29例;年龄7～15岁.其中单纯性肥胖儿童40例;超重儿童22例;健康对照儿童24例.采用酶联免疫吸附法检测各组儿童血清visfatin、ASP水平.结果 1.肥胖组血清visfatin与健康对照组和超重组相比,分别增加了49.80％(P＜0.05)、35.88％ (P ＜0.05).肥胖组血清ASP与健康对照组和超重组相比,分别增加了7.34％ (P ＜0.01)和5.57％(P＜0.05).超重组和健康对照组血清visfatin及ASP比较差异均无统计学意义.2.肥胖组体质量指数(BMI)、总胆固醇、三酰甘油、低密度脂蛋白、空腹血糖、空腹胰岛素、胰岛素抵抗指数均高于健康对照组,差异均有统计学意义(P均＜0.05);肥胖组高密度脂蛋白和胰岛素敏感指数明显低于健康对照组,差异均有统计学意义(P均＜0.05);肥胖组BMI、空腹胰岛素、胰岛素抵抗指数均高于超重组,差异均有统计学意义(P均＜0.01).3.相关性分析:血清visfatin与BMI、三酰甘油均呈正相关(r =0.218,P＜0.05;r =0.500,P＜0.01).血清ASP与BMI、总胆固醇和三酰甘油均呈正相关(r=0.268,P＜0.05;r =0.250,P＜0.05;r =0.427,P＜0.01).结论 Visfatin和ASP与肥胖关系密切,均参与肥胖儿童体内脂质代谢紊乱的发生.检测血清visfatin和ASP水平将有助于判断儿童肥胖症的发展趋势,有助于评价肥胖儿童未来发生糖尿病、心血管疾病的危险程度.
목적 탐토혈청내지소(visfatin)화촉선화단백(ASP)여단순성비반증인동발병적관계급기대비반증방치적의의.방법 연구대상공86례,남57례,녀29례;년령7～15세.기중단순성비반인동40례;초중인동22례;건강대조인동24례.채용매련면역흡부법검측각조인동혈청visfatin、ASP수평.결과 1.비반조혈청visfatin여건강대조조화초중조상비,분별증가료49.80％(P＜0.05)、35.88％ (P ＜0.05).비반조혈청ASP여건강대조조화초중조상비,분별증가료7.34％ (P ＜0.01)화5.57％(P＜0.05).초중조화건강대조조혈청visfatin급ASP비교차이균무통계학의의.2.비반조체질량지수(BMI)、총담고순、삼선감유、저밀도지단백、공복혈당、공복이도소、이도소저항지수균고우건강대조조,차이균유통계학의의(P균＜0.05);비반조고밀도지단백화이도소민감지수명현저우건강대조조,차이균유통계학의의(P균＜0.05);비반조BMI、공복이도소、이도소저항지수균고우초중조,차이균유통계학의의(P균＜0.01).3.상관성분석:혈청visfatin여BMI、삼선감유균정정상관(r =0.218,P＜0.05;r =0.500,P＜0.01).혈청ASP여BMI、총담고순화삼선감유균정정상관(r=0.268,P＜0.05;r =0.250,P＜0.05;r =0.427,P＜0.01).결론 Visfatin화ASP여비반관계밀절,균삼여비반인동체내지질대사문란적발생.검측혈청visfatin화ASP수평장유조우판단인동비반증적발전추세,유조우평개비반인동미래발생당뇨병、심혈관질병적위험정도.
Objective To explore the relationship between visfatin,acylation stimulated protein (ASP) and the incidence of childhood obesity and the significance of them in diagnoses and therapy of children's obesity.Methods Eighty-six children(57 boys and 29 girls)including 40 obese children,22 overweight children and 24 healthy control children were recruited with ages ranged 7-15 years.Serum visfatin and ASP levels were determined by enzyme linked immunosorbent assay(ELISA).Results 1.Compared with healthy and overweight children,serum visfatin level was significantly higher in obese children(P ＜ 0.05) ;Compared with healthy children and overweight children,serum ASP levels were significantly higher in obese children (P ＜ 0.01,0.05).There were no differences of serum visfatin and ASP levels between healthy and overweight children.2.The body mass index (BMI),total cholesterol (TC),triglycerides (TG),low density lipoprotein-cholesterol (LDL-C),fasting plasma glucose (FPG),fasting insulin (FINS),insulin resistance index of the obese children were higher than those of the healthy children(all P ＜0.05) ;the high density lipoprotein-cholesterol(HDL-C) and insulin sensitivity index of the obese children were lower than those of the healthy group (all P ＜ 0.05).The BMI,FINS,insulin resistance index of the obese children were higher than those of the overweight children (P ＜ 0.01).3.Correlation analysis:serum visfatin,BMI and TG were positively correlated (r =0.218,P ＜ 0.05 ; r =0.500,P ＜ 0.01,respectively).ASP and BMI,TC,TG were positively correlated (r =0.268,P ＜ 0.05 ; r=0.250,P＜0.05;r=0.427,P＜0.01,respectively).Conclusions In simple obesity children,there was a significant change in serum visfatin and ASP,and visfatin and ASP were involved in the disorder of lipids metabolism in obese children.Serum visfatin and ASP levels can be used as a new indicator to evaluate the risk of childhood obesity trends and future evaluation of diabetes and cardiovascular diseases.