CAJ | 학술논문

目的评价盐酸氨溴索静脉给药应用于有创机械通气患者的效果.方法检索Cochrane Library、PubMed、Elsevier (ScienceDirect)、OVID系列医学数据库、中国学术期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、万方数据库,搜集关于盐酸氨溴索静脉给药治疗有创机械通气患者的临床随机对照实验文献.采用RevMan5.0软件对检索到的文献进行Meta分析.结果 14篇文献纳入研究,共计1 184例机械通气患者.Meta分析结果表明:观察组血气分析、动脉二氧化碳分压指标水平均优于对照组,差异有统计学意义.观察组气道阻力及压力、气道峰压、平均气道压、内源性呼气末正压均低于对照组,差异有统计学意义.观察组肺顺应性、动态顺应性均优于对照组,差异有统计学意义.祛痰效果、呼吸机相关性肺炎发生率和pH,2组间比较差异无统计学意义.结论氨溴索静脉用药可以改善有创机械通气患者呼吸力学状态,需要大样本多中心高质量的随机对照试验进一步证实其疗效.
목적 평개염산안추색정맥급약응용우유창궤계통기환자적효과.방법 검색Cochrane Library、PubMed、Elsevier (ScienceDirect)、OVID계렬의학수거고、중국학술기간전문수거고(CNKI)、중문과기기간전문수거고(VIP)、만방수거고,수집관우염산안추색정맥급약치료유창궤계통기환자적림상수궤대조실험문헌.채용RevMan5.0연건대검색도적문헌진행Meta분석.결과 14편문헌납입연구,공계1 184례궤계통기환자.Meta분석결과표명:관찰조혈기분석、동맥이양화탄분압지표수평균우우대조조,차이유통계학의의.관찰조기도조력급압력、기도봉압、평균기도압、내원성호기말정압균저우대조조,차이유통계학의의.관찰조폐순응성、동태순응성균우우대조조,차이유통계학의의.거담효과、호흡궤상관성폐염발생솔화pH,2조간비교차이무통계학의의.결론 안추색정맥용약가이개선유창궤계통기환자호흡역학상태,수요대양본다중심고질량적수궤대조시험진일보증실기료효.
Objective To evaluate the therapeutic effect of intravenously use of ambroxol in treatment of mechanical ventilator patients.Methods Meta-analysis was used.The Cochrane Library,PubMed,Elsevier (ScienceDirect),OVID series medical databases and domestic main databases were searched,the quality of included studies was evaluated by certain standards.The Review Manager 5.0 software was used for analysis.Results 14 studies were included,1 184 mechanical ventilation patients were involved.The Meta-analysis showed that there were significant differences between two groups in blood gas analysis,airway resistance and pressure and lung compliance.However,there were no differences between two groups in expectorant effect and VAP incidence.Conclusions Intravenously use of ambroxol in treatment of mechanical ventilator patients was effective.A large multi-center sample of high-quality clinical studies is needed to confirm the results.