CAJ | 학술논문

目的研究氯化钾氯化钠注射液对血管的刺激性.方法将16只新西兰兔随机分为2组各8只,按照临床常规补钾的最高剂量和最大输注速度,在兔耳缘静脉以同等滴速和同等输液量分别静脉滴注给予氯化钾氯化钠注射液或生理盐水,盲法观察用药局部的血管、周围组织及病理图片,对比2组对血管的刺激性.结果氯化钾氯化钠注射液组与生理盐水组均未出现充血、肿胀、坏死等血管刺激性反应;亦未见炎性反应细胞浸润、细胞坏死等病理改变.结论未发现氯化钾氯化钠注射液对动物模型静脉血管壁的刺激性.
목적 연구록화갑록화납주사액대혈관적자격성.방법 장16지신서란토수궤분위2조각8지,안조림상상규보갑적최고제량화최대수주속도,재토이연정맥이동등적속화동등수액량분별정맥적주급여록화갑록화납주사액혹생리염수,맹법관찰용약국부적혈관、주위조직급병리도편,대비2조대혈관적자격성.결과 록화갑록화납주사액조여생리염수조균미출현충혈、종창、배사등혈관자격성반응;역미견염성반응세포침윤、세포배사등병리개변.결론 미발현록화갑록화납주사액대동물모형정맥혈관벽적자격성.
Objective To investigate the potential vascular stimulation of potassium chloride and sodium chloride injection.Methods Sixteen rabbits were divided equally into two groups:group one and group two,with six rabbits in each group.According to the highest dose and maximum infusion speed for routine potassium supplementation in clinic,potassium chloride and sodium chloride injection or 0.9％ sodium chloride injection was administrated,respectively,at the same infusion speed and the same infusion volume via the marginal ear veins of rabbits.The vascular stimulation and the pathological changes of marginal ear vein and its surrounding tissue of rabbits were observed by the blinding method.Results Vascular stimulation,including hyperaemia,tumidness,necrosis and pathological changes,such as inflammatory cell infiltration and cellular necrosis,were not found in two groups.Conclusions Potassium chloride and sodium chloride injection has no stimulation to the wall of blood vessels.