CAJ | 학술논문

目的探讨静脉留置针不同留置时间静脉血栓形成与vWF、DD浓度变化的关系,寻找早期预测静脉血栓形成的敏感指标,为选择干预时机提供理论和实验依据.方法选择36只实验兔随机分为甘露醇组和生理盐水组各18只,在兔耳缘静脉置入留置针并留置输液,分别测定甘露醇组和生理盐水组不同留置时间vWF和DD的浓度变化,同时病理学观察置针血管静脉血栓形成情况.结果血清学检测结果:(1)vWF浓度:置针1d时,2组vWF浓度达到高峰.(2)DD浓度:置针后2组DD浓度均高于置针前,其中置针1、3d时DD浓度与置针前比较差异有统计学意义.病理学观察结果:置针1d时,2组静脉血栓形成率达100％,血栓程度为中度以上.结论 vWF和DD浓度的测定对预测留置针致静脉血栓形成有一定的参考价值,静脉留置针置入后应尽早进行干预,防止静脉血栓形成.
목적 탐토정맥류치침불동류치시간정맥혈전형성여vWF、DD농도변화적관계,심조조기예측정맥혈전형성적민감지표,위선택간예시궤제공이론화실험의거.방법 선택36지실험토수궤분위감로순조화생리염수조각18지,재토이연정맥치입류치침병류치수액,분별측정감로순조화생리염수조불동류치시간vWF화DD적농도변화,동시병이학관찰치침혈관정맥혈전형성정황.결과 혈청학검측결과:(1)vWF농도:치침1d시,2조vWF농도체도고봉.(2)DD농도:치침후2조DD농도균고우치침전,기중치침1、3d시DD농도여치침전비교차이유통계학의의.병이학관찰결과:치침1d시,2조정맥혈전형성솔체100％,혈전정도위중도이상.결론 vWF화DD농도적측정대예측류치침치정맥혈전형성유일정적삼고개치,정맥류치침치입후응진조진행간예,방지정맥혈전형성.
Objective To observe the relations ot vWF,DD concentration and venous thrombosis caused by detaining needle of different time.Sensitive indicators for early prediction of venous thrombosis would be seeked so as to provide theoretical and experimental basis for the selection of intervention time.Methods The detaining needle were placed in the vein of rabbit ears with transfusion.The changes of vWF and DD concentration for the mannitol group and the saline group were measured in different retention time,while the venous thrombosis caused by detaining needle was observed pathologically.Results The results of serological test:(1)vWF concentration:when the needle was detained for 1 day,the vWF concentration of two groups peaked.(2)DD concentration:after the needler was set,the DD concentration of both groups was higher than those before detaining needler.When the needle was detained for 1 day and 3 days,the DD concentration was significantly different from those before using detaining needle.Result of pathological observation:When the needle was detained for 1 day,the venous throm-bosis rate was 100％ for both groups with a moderate degree of thrombosis.Conclusions Detection of the concentration of vWF and DD has certain reference value for predicting detaining needle-induced venous thrombosis.In order to prevent venous thrombosis,intervention should be carried out as soon as possible after detaining needle was set.