CAJ | 학술논문

目的探讨强化肠道水化策略对骨肉瘤新辅助化疗后的影响.方法以进行骨肉瘤新辅助化疗的29例患者为研究对象,采用随机数字表法分为两组,其中对照组(14例)采用常规水化法,实验组(15例)采用强化肠道水化策略.比较两组化疗后肝、肾功能及治疗依从性的差异.结果化疗后两组肝功能指标比较为谷丙转氨酶(ALT),丙氨酸氨基转移酶(r-GT),直接胆红素(D-Bil),白蛋白(ALB),差异均无统计学意义(t值分别为0.450,0.567,0.352,0.243;P＞0.05)；化疗后两组肾功能指标比较为血尿素氮(BUN),血肌酐(Scr),尿微量白蛋白(UMA/UCr),尿胱抑素C(UCysC/UCr),差异也均无统计学意义(t值分别为0.657,0.457,0.786,2.453;P ＞0.05).但强化肠道水化策略可明显提高患者的治疗依从性,依从性良好百分比80.0％,明显高于对照组的42.9％,两组比较,差异具有统计学意义(x2=4.243,P=0.039).结论在骨肉瘤的新辅助化疗中采用强化肠道水化策略,可在不增加患者肝肾毒性的条件下明显提高患者的治疗依从性.
목적 탐토강화장도수화책략대골육류신보조화료후적영향.방법 이진행골육류신보조화료적29례환자위연구대상,채용수궤수자표법분위량조,기중대조조(14례)채용상규수화법,실험조(15례)채용강화장도수화책략.비교량조화료후간、신공능급치료의종성적차이.결과 화료후량조간공능지표비교위곡병전안매(ALT),병안산안기전이매(r-GT),직접담홍소(D-Bil),백단백(ALB),차이균무통계학의의(t치분별위0.450,0.567,0.352,0.243;P＞0.05)；화료후량조신공능지표비교위혈뇨소담(BUN),혈기항(Scr),뇨미량백단백(UMA/UCr),뇨광억소C(UCysC/UCr),차이야균무통계학의의(t치분별위0.657,0.457,0.786,2.453;P ＞0.05).단강화장도수화책략가명현제고환자적치료의종성,의종성량호백분비80.0％,명현고우대조조적42.9％,량조비교,차이구유통계학의의(x2=4.243,P=0.039).결론 재골육류적신보조화료중채용강화장도수화책략,가재불증가환자간신독성적조건하명현제고환자적치료의종성.
Objective To investigate the effect of improved hydration on the chemotherapy of osteosarcoma.Methods A total of 29 patients were diagnosed as osteosarcoma from January 2007 to October 2011 in our hospital,14 patients take common hydration as control group,and 15 patients take new adjuvant hydration as experiment group.Compared the difference about the effect of liver renal function and treatment compliance.Results After the intervention,the liver function indexes such as alanine aminotransferase (ALT),glutamyl transpeptidase (r-GT),Direct Bilirubin (D-Bil),Albumin (ALB) of the two groups had no significant difference in two groups (t =0.450,0.567,0.352,0.243,respectively ; P ＞ 0.05).So as to the and renal function such as the indexes of blood urea nitrogen (BUN),serum creatinine (Scr),urine Microamount Albumin (UM A/UCr),and urine cystatin C (t =0.657,0.457,0.786,2.453,respectively ; P ＞ 0.05).While new adjuvant chemotherapy significantly improved the theraphy compliance in experiment group than that in control group (80.0％ vs 42.9％,X2 =4.243; P =0.039).Conclusions In the chemotherapy of osteosarcoma.improved hydration could increase the theraphy compliance of patients with no effect to liver and renal function.