CAJ | 학술논문

目的设计一种基于高级精简指令系统处理器(ARM)的无创持续气道正压(CPAP)通气呼吸机,并评价其性能.方法没计和构建CPAP呼吸机,以4例健康人为实验对象,德国德尔格RespiCare CV无创通气呼吸机作对照,验证新设计的呼吸机性能.对比两种呼吸机压力输出的稳定性、漏气补偿能力和对呼吸做功的影响.结果成功构建CPAP呼吸机.实验设计的CPAP呼吸机压力输出在2 ～ 25 cm H2O(1 cm H2O=0.098 kPa)范围内可调,输出压力稍高于设定值.当CPAP水平分别没为4、8和12 cm H2O时,实际测定的健康人气道压力均值分别为(4.35±0.32)、(9.65±0.12)和(14.07±0.36)cm H2O,高于对照呼吸机实际测定的健康人气道压力[(4.27±0.08)、(8.04±0.02)和(12.07±0.36)cmH2O](均P＜0.05).漏气实验显示设计的呼吸机CPAP水平下降了(2.41±0.03)cm H2O,高于对照呼吸机下降幅度(0.29±0.01)cm H2O(P＜0.05).当CPAP水平分别为4、8和12 cm H2O时,实验设计的呼吸机对健康人呼吸做功分别为(5.93±0.39)、(6.81±0.51)和(9.05±0.40) cm H2O/L,也高于对照呼吸机对健康人呼吸做功[(4.41±0.77)、(2.16±0.12)和(4.80±0.31)cm H2O/L](均P＜0.05).结论基于ARM处理器的无创CPAP呼吸机压力输出高于设定值,在漏气补偿和减少呼吸做功方面略显不足,然而新设计呼吸机的性能基本达到了临床使用的要求.
목적 설계일충기우고급정간지령계통처리기(ARM)적무창지속기도정압(CPAP)통기호흡궤,병평개기성능.방법 몰계화구건CPAP호흡궤,이4례건강인위실험대상,덕국덕이격RespiCare CV무창통기호흡궤작대조,험증신설계적호흡궤성능.대비량충호흡궤압력수출적은정성、루기보상능력화대호흡주공적영향.결과 성공구건CPAP호흡궤.실험설계적CPAP호흡궤압력수출재2 ～ 25 cm H2O(1 cm H2O=0.098 kPa)범위내가조,수출압력초고우설정치.당CPAP수평분별몰위4、8화12 cm H2O시,실제측정적건강인기도압력균치분별위(4.35±0.32)、(9.65±0.12)화(14.07±0.36)cm H2O,고우대조호흡궤실제측정적건강인기도압력[(4.27±0.08)、(8.04±0.02)화(12.07±0.36)cmH2O](균P＜0.05).루기실험현시설계적호흡궤CPAP수평하강료(2.41±0.03)cm H2O,고우대조호흡궤하강폭도(0.29±0.01)cm H2O(P＜0.05).당CPAP수평분별위4、8화12 cm H2O시,실험설계적호흡궤대건강인호흡주공분별위(5.93±0.39)、(6.81±0.51)화(9.05±0.40) cm H2O/L,야고우대조호흡궤대건강인호흡주공[(4.41±0.77)、(2.16±0.12)화(4.80±0.31)cm H2O/L](균P＜0.05).결론 기우ARM처리기적무창CPAP호흡궤압력수출고우설정치,재루기보상화감소호흡주공방면략현불족,연이신설계호흡궤적성능기본체도료림상사용적요구.
Objective To design the continuous positive airway pressure(CPAP) ventilator based on advanced reduced instruction set computer (RISC) machines (ARM) processor for subsequent evaluation of the performance.Methods The performance of the newly designed CPAP ventilator,including the stability of pressure output,and gas leakage compensation and the effects on the work of breathing,was assessed in 4 healthy individuals for comparison to Drager RespiCare CV non-invasive ventilator as control.Results CPAP ventilator was successfuly designed.The levels of pressure output of the newly designed ventilator were adjustable within the range from 2 to 25 cm H2O (1 cm H2O=0.098 kPa) but slightly higher than that set previously.When CPAP levels were set at 4,8 and 12 cm H2O,in the newly designed ventilator the actual airway pressures were higher (all P＜0.05) than those measured by the control ventilator [(4.35±0.32) cm H2O vs (4.27±0.08) cm H2O； (9.65±0.12) cm H2O vs (8.04±0.02) cm H2O and (14.07±0.36)cm H2O vs (12.07±0.36) cm H2O,respectively].Gas leakage test revealed a more significant reduction in thc level of CPAP for the designed ventilator as compared to control ventilator [(2.41 ± 0.03) cm H2O vs (0.29±0.01) cm H2O,P＜0.05].The established ventilator also yielded a markedly higher work of breathing (all P＜0.05) than the control ventilator [(5.93±0.39) cm H2O/L vs (4.41 ±0.77) cm H2O/L； (6.81 ±0.51)cm H2O/L vs (2.16±0.12) cm H2O/L and (9.05±0.40) cm H2O/L vs (4.80±0.31) cm H2O/L] corresponding to the CPAP levels of 4,8 and 12 cm H2O respectively.Conclusion Although the prototype ventilator based on ARM processor results in higher levels of pressure output yet insufficient capacity to compensate for the pressure drop due to gas leakage and reduce the work of breathing,the data indicate that the performance merits the criteria of clinical practice.