中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
2013年
1期
60-64
,共5页
谭理连%周洁%李志铭%余林%江金带%李树欣%张婉红
譚理連%週潔%李誌銘%餘林%江金帶%李樹訢%張婉紅
담리련%주길%리지명%여림%강금대%리수흔%장완홍
肺癌%体层摄影术,X线计算机%神经元特异性烯醇化酶
肺癌%體層攝影術,X線計算機%神經元特異性烯醇化酶
폐암%체층섭영술,X선계산궤%신경원특이성희순화매
Lung cancer%X-ray computed tomography%Neuron-specific enolase,NSE
目的 探讨周围型肺癌病理、CT表现与血清肿瘤标志物神经元特异性烯醇化酶(NSE)水平的关系.方法 回顾性分析2008年1月至2009年8月48例本院经手术病理证实的周围型肺癌患者肺癌病理、CT表现与血清肿瘤标志物NSE资料,对比分析病理、CT表现与血清肿瘤标志物NSE关系.结果 腺癌与鳞癌血清NSE浓度差异无统计学意义[(12.11±5.19)比(10.77±4.46) μg/L,P=0.098].肺癌的分化程度与血清NSE浓度无相关(r=-0.214,P=0.065).深分叶征及瘤体直径≥3 cm肺癌的血清NSE浓度较无深分叶征或瘤体直径＜3 cm高(P＜0.05).肺癌有无胸膜凹陷征、毛刺征、支气管气相,增强值≥20 Hu与＜20 Hu、钙化或肺门、纵隔淋巴结有无肿大间血清NSE浓度差异均无统计学意义(P＞0.05).肺癌Ki-67抗原阳性百分率与血清NSE浓度无相关(r=0.028,P=0.848).p53表达阴性与p53表达阳性的血清NSE浓度差异无统计学意义[(11.97±5.84)比(11.09±4.52) μ.g/L,P=0.559].结论 肺癌的深分叶征、瘤体直径≥3 cm与血清NSE浓度有关联.肺癌的分化程度、Ki-67抗原及p53表达与血清NSE浓度之间无相关.
目的 探討週圍型肺癌病理、CT錶現與血清腫瘤標誌物神經元特異性烯醇化酶(NSE)水平的關繫.方法 迴顧性分析2008年1月至2009年8月48例本院經手術病理證實的週圍型肺癌患者肺癌病理、CT錶現與血清腫瘤標誌物NSE資料,對比分析病理、CT錶現與血清腫瘤標誌物NSE關繫.結果 腺癌與鱗癌血清NSE濃度差異無統計學意義[(12.11±5.19)比(10.77±4.46) μg/L,P=0.098].肺癌的分化程度與血清NSE濃度無相關(r=-0.214,P=0.065).深分葉徵及瘤體直徑≥3 cm肺癌的血清NSE濃度較無深分葉徵或瘤體直徑＜3 cm高(P＜0.05).肺癌有無胸膜凹陷徵、毛刺徵、支氣管氣相,增彊值≥20 Hu與＜20 Hu、鈣化或肺門、縱隔淋巴結有無腫大間血清NSE濃度差異均無統計學意義(P＞0.05).肺癌Ki-67抗原暘性百分率與血清NSE濃度無相關(r=0.028,P=0.848).p53錶達陰性與p53錶達暘性的血清NSE濃度差異無統計學意義[(11.97±5.84)比(11.09±4.52) μ.g/L,P=0.559].結論 肺癌的深分葉徵、瘤體直徑≥3 cm與血清NSE濃度有關聯.肺癌的分化程度、Ki-67抗原及p53錶達與血清NSE濃度之間無相關.
목적 탐토주위형폐암병리、CT표현여혈청종류표지물신경원특이성희순화매(NSE)수평적관계.방법 회고성분석2008년1월지2009년8월48례본원경수술병리증실적주위형폐암환자폐암병리、CT표현여혈청종류표지물NSE자료,대비분석병리、CT표현여혈청종류표지물NSE관계.결과 선암여린암혈청NSE농도차이무통계학의의[(12.11±5.19)비(10.77±4.46) μg/L,P=0.098].폐암적분화정도여혈청NSE농도무상관(r=-0.214,P=0.065).심분협정급류체직경≥3 cm폐암적혈청NSE농도교무심분협정혹류체직경＜3 cm고(P＜0.05).폐암유무흉막요함정、모자정、지기관기상,증강치≥20 Hu여＜20 Hu、개화혹폐문、종격림파결유무종대간혈청NSE농도차이균무통계학의의(P＞0.05).폐암Ki-67항원양성백분솔여혈청NSE농도무상관(r=0.028,P=0.848).p53표체음성여p53표체양성적혈청NSE농도차이무통계학의의[(11.97±5.84)비(11.09±4.52) μ.g/L,P=0.559].결론 폐암적심분협정、류체직경≥3 cm여혈청NSE농도유관련.폐암적분화정도、Ki-67항원급p53표체여혈청NSE농도지간무상관.
Objective To examine the correlation of the level of serum neural specific enolase(NSE),a biomarker of tumor,with computed tomography(CT) and pathology in peripheral lung cancer.Methods Clinical profiles of pathology,features of CT and serum NSE in 48 patients with pathology-diagnosed peripheral lung cancer who underwent surgery in The Second Affiliated Hospital of Guangzhou Medical College,between January 2008 and August 2009 were retrospectively analyzed.Their correlation was examined.Results The serum NSE concentration did not differ statistically between patients with adenocarcinoma and squamous carcinoma[(12.1l±5.19)vs (10.77±4.46) μg/L,P=0.098].The serum NSE was not correlated with tumor dififerentiation (r=-0.214,P=0.065).Patients with deep lobulation sign and tumor diameter of ≥3 cm yielded higher level of serum NSE than those without(P＜0.05).There were no marked differences of serum NSE in presence of pleural indentation,spiculation and spinous protuberant sign,increased CT value by ≥20 Hu and ＜20 Hu,calcification or hilar or mediastinal lymph node enlargement(all P＞0.05).The positivity of Ki-67 antigen was not correlated significantly with serum NSE(r=0.028,P=0.848).Additionally,the difference of serum NSE in patients with and without p53 expression was not statistically significant[(11.97±5.84) vs (11.09±4.52)μg/L,P=0.559].Conclusion Serum NSE is associated with the presence of deep lobulation sign and tumor diameter of ≥3 cm in patients with peripheral lung cancer.There are no correlations of serum NSE with tumor differentiation,p53 and Ki-67 expression.
