CAJ | 학술논문

支气管哮喘(哮喘)是由多种细胞和细胞因子参与的肺部慢性炎症性疾病.目前,哮喘的相关基因尚未完全明确,但研究表明存在与气道高反应性、IgE调节和特应性反应相关的基因,这些基因在哮喘发病中起着重要作用.近年来,STAT家族在炎症性疾病及免疫性疾病中发挥的重要作用已逐渐引起人们的重视.本文就STAT家族与哮喘发病机制的研究进展做一综述.
지기관효천(효천)시유다충세포화세포인자삼여적폐부만성염증성질병.목전,효천적상관기인상미완전명학,단연구표명존재여기도고반응성、IgE조절화특응성반응상관적기인,저사기인재효천발병중기착중요작용.근년래,STAT가족재염증성질병급면역성질병중발휘적중요작용이축점인기인문적중시.본문취STAT가족여효천발병궤제적연구진전주일종술.
Bronchial asthma(asthma for short) is a chronic inflammatory disease of the lung,which is involved with various cells and cytokines.Now,the related genes of asthma is not well-known yet.But research shows that there are related genes to airway hyperreactivity,IgE regulation and atopic reaction.These genes play an important role in asthma.In recent years,it is recognized that STAT family plays an important role in inflammatory and immunological diseases.In this article the role of STAT family played in asthma pathogenesis will be reviewed.