中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2014年
1期
13-15
,共3页
王秀芳%杨慧彬%宋丽%张艳丽%许春娜
王秀芳%楊慧彬%宋麗%張豔麗%許春娜
왕수방%양혜빈%송려%장염려%허춘나
毛细支气管炎%白细胞介素-12%特应性%婴幼儿
毛細支氣管炎%白細胞介素-12%特應性%嬰幼兒
모세지기관염%백세포개소-12%특응성%영유인
Capillary bronchiolitis%Interleukin-12%Idiocrasy%Infants
目的 探讨白细胞介素(interleukin,IL)-12在毛细支气管炎发病过程中的意义.方法 选取59例2岁以下毛细支气管炎患儿,分为毛支Ⅰ组(n=28)和毛支Ⅱ组(n=31),其中毛支Ⅰ组为具有特应质高危因素的患儿,毛支Ⅱ组为无特应质高危因素的患儿.同期住院的同年龄段支气管肺炎患儿36例和患有疝气、肾结石等非感染性疾病术前患儿31例分别作为肺炎对照组和正常对照组,分别检测4组患儿外周血IL-12的水平.结果 毛支Ⅰ组患儿外周血IL-12为(34.72±7.96) pg/ml;毛支Ⅱ组患儿外周血IL-12为(55.30±6.72) pg/ml;肺炎对照组患儿及正常对照组患儿外周血IL-12分别为(56.79±10.36) pg/ml、(61.23±11.51) pg/ml,其中毛支Ⅰ组与毛支Ⅱ组相比,外周血IL-12水平降低,差异有统计学意义(P＜0.05);毛支I组与肺炎对照组、正常对照组相比,外周血IL-12水平显著降低,差异有统计学意义(P＜0.05);毛支Ⅱ组与肺炎对照组、正常对照组相比,外周血IL-12水平降低,差异有统计学意义(P＜0.05);肺炎对照组与正常对照组相比,外周血IL-12水平差异无统计学意义(P＞0.05).结论 血清IL-12降低是毛细支气管炎发病的重要因素,具有特应质高危因素的毛细支气管炎患儿IL-12降低更为明显.
目的 探討白細胞介素(interleukin,IL)-12在毛細支氣管炎髮病過程中的意義.方法 選取59例2歲以下毛細支氣管炎患兒,分為毛支Ⅰ組(n=28)和毛支Ⅱ組(n=31),其中毛支Ⅰ組為具有特應質高危因素的患兒,毛支Ⅱ組為無特應質高危因素的患兒.同期住院的同年齡段支氣管肺炎患兒36例和患有疝氣、腎結石等非感染性疾病術前患兒31例分彆作為肺炎對照組和正常對照組,分彆檢測4組患兒外週血IL-12的水平.結果 毛支Ⅰ組患兒外週血IL-12為(34.72±7.96) pg/ml;毛支Ⅱ組患兒外週血IL-12為(55.30±6.72) pg/ml;肺炎對照組患兒及正常對照組患兒外週血IL-12分彆為(56.79±10.36) pg/ml、(61.23±11.51) pg/ml,其中毛支Ⅰ組與毛支Ⅱ組相比,外週血IL-12水平降低,差異有統計學意義(P＜0.05);毛支I組與肺炎對照組、正常對照組相比,外週血IL-12水平顯著降低,差異有統計學意義(P＜0.05);毛支Ⅱ組與肺炎對照組、正常對照組相比,外週血IL-12水平降低,差異有統計學意義(P＜0.05);肺炎對照組與正常對照組相比,外週血IL-12水平差異無統計學意義(P＞0.05).結論 血清IL-12降低是毛細支氣管炎髮病的重要因素,具有特應質高危因素的毛細支氣管炎患兒IL-12降低更為明顯.
목적 탐토백세포개소(interleukin,IL)-12재모세지기관염발병과정중적의의.방법 선취59례2세이하모세지기관염환인,분위모지Ⅰ조(n=28)화모지Ⅱ조(n=31),기중모지Ⅰ조위구유특응질고위인소적환인,모지Ⅱ조위무특응질고위인소적환인.동기주원적동년령단지기관폐염환인36례화환유산기、신결석등비감염성질병술전환인31례분별작위폐염대조조화정상대조조,분별검측4조환인외주혈IL-12적수평.결과 모지Ⅰ조환인외주혈IL-12위(34.72±7.96) pg/ml;모지Ⅱ조환인외주혈IL-12위(55.30±6.72) pg/ml;폐염대조조환인급정상대조조환인외주혈IL-12분별위(56.79±10.36) pg/ml、(61.23±11.51) pg/ml,기중모지Ⅰ조여모지Ⅱ조상비,외주혈IL-12수평강저,차이유통계학의의(P＜0.05);모지I조여폐염대조조、정상대조조상비,외주혈IL-12수평현저강저,차이유통계학의의(P＜0.05);모지Ⅱ조여폐염대조조、정상대조조상비,외주혈IL-12수평강저,차이유통계학의의(P＜0.05);폐염대조조여정상대조조상비,외주혈IL-12수평차이무통계학의의(P＞0.05).결론 혈청IL-12강저시모세지기관염발병적중요인소,구유특응질고위인소적모세지기관염환인IL-12강저경위명현.
Objective To discuss the role of interleukin (IL)-12 in capillary bronchiolitis disease.Methods Fifty-nine cases of capillary bronchiolitis children under 2 years old were enrolled as the bronchiolitis group Ⅰ(n =28) and bronchiolitis group Ⅱ(n =31),36 cases of children with bronchopneumonia of the same age and 31 cases of children suffered from non-infectious diseases such as hernia and renal calculus of the same age were enrolled as bronchopneumonia control group and normal control group respectively.The peripheral blood IL-12 levels of four groups were detected by enzyme-linked immunosorbent assay.Results The levels of the peripheral blood IL-12 in bronchiolitis group Ⅰ,bronchiolitis group Ⅱ,bronchopneumonia control group and normal control group were (34.72±7.96) pg/ml,(55.30 ±6.72) pg/ml,(56.79±10.36) pg/ml and (61.23 ± 11.51) pg/ml respectively.The level of the peripheral blood IL-12 in bronchiolitis group I was significantly lower than that in bronchiolitis group Ⅱ,bronchopneumonia control group and normal control group respectively (P ＜0.05),and the level of the peripheral blood IL-12 in bronchiolitis group ⅡⅡ was significantly lower than that in bronchopneumonia control group and normal control group respectively (P ＜ 0.05),but there was no significant difference between bronchopneumonia control group and normal control group (P ＞ 0.05).Conclusion The level of IL-12 is one of the important factors for bronchiolitis disease,the reducing of serum level of IL-12 in children who have a high risk factor of capillary bronchiolitis is more obvious.
