中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2014年
1期
31-33
,共3页
陆彩霞%李春娥%李筠%姚泽忠
陸綵霞%李春娥%李筠%姚澤忠
륙채하%리춘아%리균%요택충
肺炎支原体肺炎%神经生长因子%白细胞介素-15
肺炎支原體肺炎%神經生長因子%白細胞介素-15
폐염지원체폐염%신경생장인자%백세포개소-15
Mycoplasma pneumoniae pneumonia%Nerve growth factor%Interleukin-15
目的 探讨肺炎支原体肺炎(mycoplasma pneumoniae pneumonia,MPP)患儿血清中神经生长因子(nerve growth factor,NGF)、白细胞介素(interleukin,IL)-15的水平变化及其临床意义.方法 采用酶联免疫吸附法对65例MPP患儿(重症组25例,轻症组40例)和50例健康儿童(对照组)的血清NGF和IL-15水平进行测定.结果 检测血清NGF、IL-15水平,MPP组急性期分别为(157.62±33.45) pg/ml和(242.51 ±60.04) pg/ml,恢复期分别为(99.58 ±21.29) pg/ml和(145.90±50.25)pg/ml,均较对照组明显升高[(29.86±11.74) pg/ml,(108.86 ±21.14) pg/ml],且急性期NGF、IL-15水平显著高于恢复期,差异有统计学意义(P＜0.05).在MPP急性期,重症组血清NGF、IL-15水平显著高于轻症组[(204.38±27.52) pg/ml vs(128.39±22.07) pg/ml,(288.58±55.33) pg/ml vs (213.71±42.69) pg/ml],差异有统计学意义(P＜0.05);在MPP恢复期,重症组血清NGF、IL-15水平高于轻症组,差异无统计学意义(P＞0.05).结论 肺炎支原体感染后,患儿血清中NGF、IL-15水平明显升高,随着病情的缓解而降低,提示NGF、IL-15参与肺炎支原体感染的发病过程.
目的 探討肺炎支原體肺炎(mycoplasma pneumoniae pneumonia,MPP)患兒血清中神經生長因子(nerve growth factor,NGF)、白細胞介素(interleukin,IL)-15的水平變化及其臨床意義.方法 採用酶聯免疫吸附法對65例MPP患兒(重癥組25例,輕癥組40例)和50例健康兒童(對照組)的血清NGF和IL-15水平進行測定.結果 檢測血清NGF、IL-15水平,MPP組急性期分彆為(157.62±33.45) pg/ml和(242.51 ±60.04) pg/ml,恢複期分彆為(99.58 ±21.29) pg/ml和(145.90±50.25)pg/ml,均較對照組明顯升高[(29.86±11.74) pg/ml,(108.86 ±21.14) pg/ml],且急性期NGF、IL-15水平顯著高于恢複期,差異有統計學意義(P＜0.05).在MPP急性期,重癥組血清NGF、IL-15水平顯著高于輕癥組[(204.38±27.52) pg/ml vs(128.39±22.07) pg/ml,(288.58±55.33) pg/ml vs (213.71±42.69) pg/ml],差異有統計學意義(P＜0.05);在MPP恢複期,重癥組血清NGF、IL-15水平高于輕癥組,差異無統計學意義(P＞0.05).結論 肺炎支原體感染後,患兒血清中NGF、IL-15水平明顯升高,隨著病情的緩解而降低,提示NGF、IL-15參與肺炎支原體感染的髮病過程.
목적 탐토폐염지원체폐염(mycoplasma pneumoniae pneumonia,MPP)환인혈청중신경생장인자(nerve growth factor,NGF)、백세포개소(interleukin,IL)-15적수평변화급기림상의의.방법 채용매련면역흡부법대65례MPP환인(중증조25례,경증조40례)화50례건강인동(대조조)적혈청NGF화IL-15수평진행측정.결과 검측혈청NGF、IL-15수평,MPP조급성기분별위(157.62±33.45) pg/ml화(242.51 ±60.04) pg/ml,회복기분별위(99.58 ±21.29) pg/ml화(145.90±50.25)pg/ml,균교대조조명현승고[(29.86±11.74) pg/ml,(108.86 ±21.14) pg/ml],차급성기NGF、IL-15수평현저고우회복기,차이유통계학의의(P＜0.05).재MPP급성기,중증조혈청NGF、IL-15수평현저고우경증조[(204.38±27.52) pg/ml vs(128.39±22.07) pg/ml,(288.58±55.33) pg/ml vs (213.71±42.69) pg/ml],차이유통계학의의(P＜0.05);재MPP회복기,중증조혈청NGF、IL-15수평고우경증조,차이무통계학의의(P＞0.05).결론 폐염지원체감염후,환인혈청중NGF、IL-15수평명현승고,수착병정적완해이강저,제시NGF、IL-15삼여폐염지원체감염적발병과정.
Objective To investigate the changes of serum nerve growth factor(NGF) and interleukin(IL)-15 levels in children with mycoplasma pneumoniae pneumonia(MPP) and its clinical significance.Methods Using the antibody sandwich ELISA method to measure the serum NGF and IL-15 levels in 65 cases of MPP (MPP group,which contains two groups:the severe group contains 25 patients and the mild group contains 40 patients) and 50 cases of healthy children (normal control group).Results The serum NGF,IL-15 levels in the acute phase of MPP group were (157.62 ± 33.45) pg/ml and (242.51 ± 60.04) pg/ml,and in the recovery period were (99.58 ±21.29) pg/ml and (145.90 ±50.25) pg/ml,they were all significantly higher than the normal control group [(29.86-± 11.74) pg/ml and (108.86 ± 21.14) pg/ml,P ＜ 0.05].The serum NGF,IL-15 of the acute phase were also higher than the recovery period (P ＜0.05).In the acute phase of MPP,serum NGF,IL-15 levels in the severe group were significantly higher than in the mild group [(204.38±27.52) pg/ml vs (128.39 ±22.07) pg/ml,(288.58 ±55.33) pg/ml vs (213.71 ±42.69) pg/ml],and the differences were statistically significant (P ＜ 0.05) ; in the recovery period of MPP group,the serum NGF,IL-15 levels of severe group were higher than the mild group,but the difference was not statistically significant (P ＞0.05).Conclusion The serum levels of NGF,IL-15 in the mycoplasma pneumoniae infection patients are significantly increased,and they are all decreased as the disease mitigation.It is prompted that NGF and IL-15 participate in the pathogenesis of infection by mycoplasma pneumoniae.
