中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2014年
10期
667-670
,共4页
中性粒细胞明胶酶相关脂质运载蛋白%急性肾损伤%标志物%早期诊断
中性粒細胞明膠酶相關脂質運載蛋白%急性腎損傷%標誌物%早期診斷
중성립세포명효매상관지질운재단백%급성신손상%표지물%조기진단
Neutrophil gelatinase-associated lipocalin%Acute kidney injury%Biomarker%Early diagnosis
中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)是脂质蛋白家族成员之一,首先于中性粒细胞中分离得到的一种稳定多肽.作为新型临床早期诊断急性肾损伤的标志物,NGAL不易受机体、药物及肾外因素影响,血液和尿液中浓度升高都可以预测急性肾损伤.动态监测NGAL可以评估临床治疗手段是否有效,对急性肾损伤的救治有参考意义.
中性粒細胞明膠酶相關脂質運載蛋白(neutrophil gelatinase-associated lipocalin,NGAL)是脂質蛋白傢族成員之一,首先于中性粒細胞中分離得到的一種穩定多肽.作為新型臨床早期診斷急性腎損傷的標誌物,NGAL不易受機體、藥物及腎外因素影響,血液和尿液中濃度升高都可以預測急性腎損傷.動態鑑測NGAL可以評估臨床治療手段是否有效,對急性腎損傷的救治有參攷意義.
중성립세포명효매상관지질운재단백(neutrophil gelatinase-associated lipocalin,NGAL)시지질단백가족성원지일,수선우중성립세포중분리득도적일충은정다태.작위신형림상조기진단급성신손상적표지물,NGAL불역수궤체、약물급신외인소영향,혈액화뇨액중농도승고도가이예측급성신손상.동태감측NGAL가이평고림상치료수단시부유효,대급성신손상적구치유삼고의의.
Neutrophil gelatinase-associated lipocalin(NGAL) is a new member of lipid protein family,which is a kind of stable polypeptide firstly separated from neutrophils.As a new biomarker of acute kidney injury(AKI) for early clinical diagnosis.NGAL is less easily affected by factors such as the body itself,drugs or aspects outside kidney.The high levels of NGAL in the blood and urine can both predict AKI.Dynamic monitoring NGAL can assess the validity of clinical therapy and give reference to treatment of AKI.
