CAJ | 학술논문

TACE是原发性肝癌非手术治疗的首选方法,但肿瘤难根治,不易处理肝外转移灶,且多次治疗加重肝损伤,远期疗效较差.索拉非尼可以控制肿瘤血管生成,抑制肿瘤细胞增殖.本文报道2009年2月河南省肿瘤医院对1例中国肝癌分期Ⅱb期的原发性肝癌初诊患者进行TACE联合索拉非尼和抗病毒治疗,患者肝内病灶无活性,肺内转移灶达部分缓解.随访至2012年5月,患者生存39个月,肝功能正常,HBV DNA转为阴性,无介入并发症,卡氏评分100分.
TACE시원발성간암비수술치료적수선방법,단종류난근치,불역처리간외전이조,차다차치료가중간손상,원기료효교차.색랍비니가이공제종류혈관생성,억제종류세포증식.본문보도2009년2월하남성종류의원대1례중국간암분기Ⅱb기적원발성간암초진환자진행TACE연합색랍비니화항병독치료,환자간내병조무활성,폐내전이조체부분완해.수방지2012년5월,환자생존39개월,간공능정상,HBV DNA전위음성,무개입병발증,잡씨평분100분.
Transcatheter arterial chemoembolization (TACE) was the preferred method of non-operation treatment for hepatocellular carcinoma (HCC).Radical resection of HCC remains difficult,extrahepatic metastasis was not easy to deal with,and repeated treatment aggravated the liver injury,so the long-term efficacy was poor.Sorafenib could control tumor angiogenesis and block the proliferation of tumor cells.A male patient with primary HCC and in the stage Ⅱb according to the Chinese clinical liver cancer staging system was treated by TACE combined with sorafenib and antiviral treatment in Henan Cancer Hospital.After the treatment,the intrahepatic lesions were inactive,and the pulmonary metastasis was partially relieved.The patient was followed up till May 2012,and the survival time was 39 months.The hepatic function was normal,and the hepatitis B virus (HBV) replication was negative.No intervention treatmentrelated complications were detected,and the KPS score was 100.