CAJ | 학술논문

表观遗传学是指基因的核苷酸序列在不发生改变的情况下,基因表达了可遗传的表型变化.表观遗传机制的失调在人类恶性肿瘤包括肝癌发生、发展过程中发挥了重要作用.目前研究结果发现:大量表观遗传可调节有关基因靶点和信号转导通路,如DNA甲基化、组蛋白修饰、RNA调节基因沉默等与肝癌的发生和发展密切相关.探究这些异常的表观遗传机制对诊断和治疗肝癌有着重要的意义.
표관유전학시지기인적핵감산서렬재불발생개변적정황하,기인표체료가유전적표형변화.표관유전궤제적실조재인류악성종류포괄간암발생、발전과정중발휘료중요작용.목전연구결과발현:대량표관유전가조절유관기인파점화신호전도통로,여DNA갑기화、조단백수식、RNA조절기인침묵등여간암적발생화발전밀절상관.탐구저사이상적표관유전궤제대진단화치료간암유착중요적의의.
Epigenetics refers to steady phenotypic changes in gene expression without modifications in the genetic nucleotide sequence.Disorder of epigenetic mechanisms plays an important role in the occurrence and development of human malignant tumors including hepatocellular carcinoma.A large number of gene targets and pathways related to epigenetics were discovered.For instance,DNA methylation,histone modification and RNA regulator gene silencing were associated with the development of hepatocellular carcinoma.Exploring the abnormal epigenetics is of great significance for prevention and treatment of hepatocellular carcinoma.