中华消化外科杂志
中華消化外科雜誌
중화소화외과잡지
CHINESE JOURNAL OF DIGESTIVE SURGERY
2014年
1期
34-38
,共5页
吴迪%李玉民%曹文娟%刘涛%曾祥挺
吳迪%李玉民%曹文娟%劉濤%曾祥挺
오적%리옥민%조문연%류도%증상정
胃肿瘤%白细胞介素10%基因多态性%Meta分析
胃腫瘤%白細胞介素10%基因多態性%Meta分析
위종류%백세포개소10%기인다태성%Meta분석
Gastric neoplasms%Interleukin-10%Gene polymorphism%Meta analysis
目的 系统分析中国人群白细胞介素10-1082(IL-10-1082)基因多态性与胃癌遗传易感性的关系.方法 采用Cochrane系统评价方法,检索1966年至2012年Medline、Embase、Cochrane Library、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CJFD)和中国科技期刊全文数据库(CSJD)等数据库,收集IL-10-1082基因多态性与中国人群胃癌易感性的病例对照研究.将纳入研究的胃癌患者作为胃癌组,健康人群作为健康对照组.由2名研究者独立提取数据和进行文献质量评价,综合评价IL-10-1082位点基因型GG与AA、AG与AA及等位基因G与A在中国人胃癌组与健康对照组中是否有差异.采用Q检验和I2对异质性进行定量分析.采用固定或随机效应模型合并数据.计数资料采用优势比(OR)及95％可信区间(95％ CI)表示.结果 共纳入13篇文献,累计样本量5252例,其中胃癌组患者2077例,健康对照组人群3175例.Meta分析结果显示:携带IL-10-1082基因型GG与AG患者,其胃癌发生风险率高于与携带IL-10-1082基因型AA患者(OR=1.76,95％CI 1.33 ～2.33;OR =2.08,95％ CI 1.62 ～2.66,P＜0.05)；IL-10-1082基因型具有等位基因G的患者其胃癌发生风险率高于含等位基因A的患者(OR=1.67,95％CI.31 ～2.13,P＜0.05).结论 中国人群IL-10-1082基因型GG、AG及等位基因G与胃癌发生有关.
目的 繫統分析中國人群白細胞介素10-1082(IL-10-1082)基因多態性與胃癌遺傳易感性的關繫.方法 採用Cochrane繫統評價方法,檢索1966年至2012年Medline、Embase、Cochrane Library、中國生物醫學文獻數據庫(CBM)、中國期刊全文數據庫(CJFD)和中國科技期刊全文數據庫(CSJD)等數據庫,收集IL-10-1082基因多態性與中國人群胃癌易感性的病例對照研究.將納入研究的胃癌患者作為胃癌組,健康人群作為健康對照組.由2名研究者獨立提取數據和進行文獻質量評價,綜閤評價IL-10-1082位點基因型GG與AA、AG與AA及等位基因G與A在中國人胃癌組與健康對照組中是否有差異.採用Q檢驗和I2對異質性進行定量分析.採用固定或隨機效應模型閤併數據.計數資料採用優勢比(OR)及95％可信區間(95％ CI)錶示.結果 共納入13篇文獻,纍計樣本量5252例,其中胃癌組患者2077例,健康對照組人群3175例.Meta分析結果顯示:攜帶IL-10-1082基因型GG與AG患者,其胃癌髮生風險率高于與攜帶IL-10-1082基因型AA患者(OR=1.76,95％CI 1.33 ～2.33;OR =2.08,95％ CI 1.62 ～2.66,P＜0.05)；IL-10-1082基因型具有等位基因G的患者其胃癌髮生風險率高于含等位基因A的患者(OR=1.67,95％CI.31 ～2.13,P＜0.05).結論 中國人群IL-10-1082基因型GG、AG及等位基因G與胃癌髮生有關.
목적 계통분석중국인군백세포개소10-1082(IL-10-1082)기인다태성여위암유전역감성적관계.방법 채용Cochrane계통평개방법,검색1966년지2012년Medline、Embase、Cochrane Library、중국생물의학문헌수거고(CBM)、중국기간전문수거고(CJFD)화중국과기기간전문수거고(CSJD)등수거고,수집IL-10-1082기인다태성여중국인군위암역감성적병례대조연구.장납입연구적위암환자작위위암조,건강인군작위건강대조조.유2명연구자독립제취수거화진행문헌질량평개,종합평개IL-10-1082위점기인형GG여AA、AG여AA급등위기인G여A재중국인위암조여건강대조조중시부유차이.채용Q검험화I2대이질성진행정량분석.채용고정혹수궤효응모형합병수거.계수자료채용우세비(OR)급95％가신구간(95％ CI)표시.결과 공납입13편문헌,루계양본량5252례,기중위암조환자2077례,건강대조조인군3175례.Meta분석결과현시:휴대IL-10-1082기인형GG여AG환자,기위암발생풍험솔고우여휴대IL-10-1082기인형AA환자(OR=1.76,95％CI 1.33 ～2.33;OR =2.08,95％ CI 1.62 ～2.66,P＜0.05)；IL-10-1082기인형구유등위기인G적환자기위암발생풍험솔고우함등위기인A적환자(OR=1.67,95％CI.31 ～2.13,P＜0.05).결론 중국인군IL-10-1082기인형GG、AG급등위기인G여위암발생유관.
Objective To assess the association between interleukin-10-1082 (IL-10-1082) gene polymorphisms and susceptibility of gastric cancer in the Chinese population.Methods Cochrane systematic evaluation was adopted for the analysis.Articles published in Medline,Embase,Cochrane library,CBM,CJFD and CSJD from 1966 to 2012 were retrieved.Case control studies on the correlation between the 1L-10-1082 polymorphism and gastric cancer in Chinese population were collected.Gastric cancer patients were in the gastric cancer group,and healthy individuals were in the control group.Two researchers extracted data and evaluated the quality of literatures independently.Meta analysis was performed to detect whether there were differences between the gastric cancer group and the control group about the distribution of genotypes of IL-10-1082 gene (GG,AA,AG,AA,alleles G and A).The heterogeneity was analyzed using the Q test or I2 test.Fixed effect model or random effect model was adopted,and the results of the meta analysis were presented with odds ratio (OR) and 95％ confidence interval (95％ CI).Results Thirteen literatures including 5252 patients were included in the analysis.There were 2077 patients in the gastric cancer group and 3175 patients in the control group.The results of meta analysis showed that population with the genotypes GG and AG have higher risk of having gastric cancer when compared with population with the genotype AA (OR =1.76,95％ CI 1.33-2.33 ; OR =2.08,95％ CI 1.62-2.66,P ＜0.05).Population with the allele G have higher risk of having gastric cancer when compared with population with allele A (OR =1.67,95％ CI 1.31-2.13,P ＜ 0.05).Conclusion The genotypes GG,AG and the allele G of IL-10-1082 gcne of the Chincse population are significantly associated with the increased risk of gastric cancer.
