CAJ | 학술논문

Toll样受体(TLRs)是先天性免疫的病原模式识别受体,在病原体的识别、获得性免疫反应的调节、信号转导等方面起重要作用.随着对感染性角膜炎和角膜移植术后急性、慢性排斥反应发生机制研究的深入,TLRs在角膜免疫应答中的诱导和调控作用日益受到研究者的关注.目前对TLRs激活细菌性角膜疾病、真菌性角膜疾病、病毒性角膜疾病、角膜移植后植片排斥反应等炎症过程中的免疫信号通路已有较多研究,对TLRs及其信号系统表达的调控有助于减轻或阻止上述炎症反应过程.就TLRs、TLRs信号转导途径及其对角膜炎症反应的免疫调控机制进行综述,探讨其关键作用及可能的治疗靶点.
Toll양수체(TLRs)시선천성면역적병원모식식별수체,재병원체적식별、획득성면역반응적조절、신호전도등방면기중요작용.수착대감염성각막염화각막이식술후급성、만성배척반응발생궤제연구적심입,TLRs재각막면역응답중적유도화조공작용일익수도연구자적관주.목전대TLRs격활세균성각막질병、진균성각막질병、병독성각막질병、각막이식후식편배척반응등염증과정중적면역신호통로이유교다연구,대TLRs급기신호계통표체적조공유조우감경혹조지상술염증반응과정.취TLRs、TLRs신호전도도경급기대각막염증반응적면역조공궤제진행종술,탐토기관건작용급가능적치료파점.
As pattern recognition receptors of innate immunity,Toll-like receptors (TLRs) play an important role in the identification of pathogens,regulation of adaptive immunity and signal transduction.With more exploration of the mechanism of microbial keratitis and the acute or chronic rejection after penetrating keratoplasty,the induction and regulation of TLRs on the corneal immune response is increasingly concerned.Up to now,more and more studies of immune signal pathway of TLRs in mediating inflammatory response of bacterial keratitis,fungal keratitis,viral keratitis and graft rejection have been documented.To regulate the expression of TLRs is undoubtedly available for lightening and arresting the immuno-inflammatory response.Here,the current knowledge about TLRs,their signal transduction pathway and their regulation on corneal immunity are summarized,aiming to discuss their significant effects and the potential therapeutic targets.