CAJ | 학술논문

趋化因子是机体内一组具有趋化作用的细胞因子,主要表达于中性粒细胞、单核细胞、巨噬细胞、T淋巴细胞和B淋巴细胞,眼部的组织细胞及免疫活性细胞亦可分泌产生多种趋化因子.研究表明,趋化因子在炎症反应、感染、创伤愈合、免疫调节、血管发生、肿瘤的侵袭和转移等生理病理过程中发挥重要作用.高糖、缺氧、氧化应激等因素刺激眼部组织细胞上调CXC趋化因子、CC趋化因子的表达,参与脉络膜新生血管(CNV)及眼部新生血管性疾病的发展.就趋化因子的基本概念和功能以及其与常见眼部新生血管性疾病,如糖尿病视网膜病变(DR)、年龄相关性黄斑变性(AMD)的关系进行综述.
추화인자시궤체내일조구유추화작용적세포인자,주요표체우중성립세포、단핵세포、거서세포、T림파세포화B림파세포,안부적조직세포급면역활성세포역가분비산생다충추화인자.연구표명,추화인자재염증반응、감염、창상유합、면역조절、혈관발생、종류적침습화전이등생리병리과정중발휘중요작용.고당、결양、양화응격등인소자격안부조직세포상조CXC추화인자、CC추화인자적표체,삼여맥락막신생혈관(CNV)급안부신생혈관성질병적발전.취추화인자적기본개념화공능이급기여상견안부신생혈관성질병,여당뇨병시망막병변(DR)、년령상관성황반변성(AMD)적관계진행종술.
Chemokine is a family of small chemotactic cytokines.Chemokine mainly locates in neutrophile granulocyte,monocyte,macrophage,T lymphocyte and B lymphocyte,and some cells and immunoactive cells also secret cytokines.Researches showed that chemokine plays important roles in many patho-physiological activities,such as inflammatory response,infection procedure,wound healing,regulation of immunity,angiogenesis,invasion and metastases of cancer,etc..Some chemokine factors,such as hyperglycemia,hypoxia,oxidative stress,stimulate the ocular histiocytes to up-regulate the expressions of CXC chemokines and CC chemokines,which participate in the development of choroidal neovascularization and ocular neovascular diseases.This article reviews current progress in chemokine and the relationship between chemokines and ocular neovascular diseases,especially in diabetic retinopathy (DR) and age-related macular degeneration (AMD) etc..