中华实验眼科杂志
中華實驗眼科雜誌
중화실험안과잡지
CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY
2013年
9期
902-904
,共3页
糖尿病视网膜病变%泛素-蛋白酶体途径%转化生长因子-β/Smads信号传导通路
糖尿病視網膜病變%汎素-蛋白酶體途徑%轉化生長因子-β/Smads信號傳導通路
당뇨병시망막병변%범소-단백매체도경%전화생장인자-β/Smads신호전도통로
Diabetic retinopathy%Ubiquitin-proteasome pathway%Transforming growth factor-β/Smads signal transduction pathway
糖尿病视网膜病变(DR)是糖尿病常见和严重的并发症之一,参与的细胞因子和调节因子众多,其发病机制一直是DR防治研究的热点.研究证实,转化生长因子-β(TGF-β)参与了DR的发生和发展,Smads蛋白则能介导TGF-β/Smads信号通路的激活,进而参与DR的病理过程,而泛素-蛋白酶体途径(UPP)中的泛素连接酶Smurf则参与了TGF-β/Smads信号通路的降解调节.目前,相关研究已经取得了较大进展,就UPP对TGF-β/Smads信号转导通路的降解调节在DR中的作用进行综述.
糖尿病視網膜病變(DR)是糖尿病常見和嚴重的併髮癥之一,參與的細胞因子和調節因子衆多,其髮病機製一直是DR防治研究的熱點.研究證實,轉化生長因子-β(TGF-β)參與瞭DR的髮生和髮展,Smads蛋白則能介導TGF-β/Smads信號通路的激活,進而參與DR的病理過程,而汎素-蛋白酶體途徑(UPP)中的汎素連接酶Smurf則參與瞭TGF-β/Smads信號通路的降解調節.目前,相關研究已經取得瞭較大進展,就UPP對TGF-β/Smads信號轉導通路的降解調節在DR中的作用進行綜述.
당뇨병시망막병변(DR)시당뇨병상견화엄중적병발증지일,삼여적세포인자화조절인자음다,기발병궤제일직시DR방치연구적열점.연구증실,전화생장인자-β(TGF-β)삼여료DR적발생화발전,Smads단백칙능개도TGF-β/Smads신호통로적격활,진이삼여DR적병리과정,이범소-단백매체도경(UPP)중적범소련접매Smurf칙삼여료TGF-β/Smads신호통로적강해조절.목전,상관연구이경취득료교대진전,취UPP대TGF-β/Smads신호전도통로적강해조절재DR중적작용진행종술.
Diabetic retinopathy (DR) is one of the common and serious diabetic complications,with a complex nosogenesis.Studies have shown that transforming growth factor-β (TGF-β) participates in the occurrence and development of DR,and Smads protein is able to mediate and activate TGF-β/Smads signal transduction pathway and further involves in the pathogenesis of DR.Smurf is one of the ubiquitin ligases in ubiquitin-proteasome pathway,and it is clarified to regulate TGF-β/Smads signal transduction pathway degradation.At present,the study on the relationship between TGF-β/Smads pathway and DR has made great progress.The role of ubiquitin-proteasome pathway regulating TGF-β/Smads signal transduction pathway in DR is reviewed in this article.
