CAJ | 학술논문

糖尿病性黄斑水肿(DME)是糖尿病患者视力丧失的首要原因,根据DME的严重程度及水肿类型、选择合适的治疗方式对于挽救患者的视力至关重要.目前,DME的治疗方法包括激光光凝、糖皮质激素的应用、抗血管内皮生长因子(VEGF)药物的玻璃体内注射、蛋白激酶C抑制剂的应用、玻璃体手术及联合治疗方法等,但每种疗法都有其优点和不足.激光光凝、玻璃体手术以及玻璃体腔内注药和植入药物缓释系统均为破坏性治疗方式,对已损坏的视网膜光感受器的功能和结构无法挽救,因此应尽早发现和诊断DME,尽量选择创伤小、不良反应少的治疗方法进行干预.本文对DME治疗的国内外研究现状及未来的发展趋势进行综述.
당뇨병성황반수종(DME)시당뇨병환자시력상실적수요원인,근거DME적엄중정도급수종류형、선택합괄적치료방식대우만구환자적시력지관중요.목전,DME적치료방법포괄격광광응、당피질격소적응용、항혈관내피생장인자(VEGF)약물적파리체내주사、단백격매C억제제적응용、파리체수술급연합치료방법등,단매충요법도유기우점화불족.격광광응、파리체수술이급파리체강내주약화식입약물완석계통균위파배성치료방식,대이손배적시망막광감수기적공능화결구무법만구,인차응진조발현화진단DME,진량선택창상소、불량반응소적치료방법진행간예.본문대DME치료적국내외연구현상급미래적발전추세진행종술.
Diabetic macular edema (DME) is a leading cause of vision loss in diabetic patients.It is very important to correctly select a treating approach for DME.At present,the treating methods of DME include retinal laser photocoagulation,application of the glucocorticoid,intravitreous injection of anti-vascular endothelial growth factor (VEGF) drugs,administration of inhibitor of protein kinase C,vitrectomy and combined treatment etc.However,each method has its advantage and disadvantage.Retinal photocoagulation,vitrectomy,intravitreous injection and drug delivery system implantation are invasive treatment methods,and they can not rescue damaged retinal photoreceptors.Therefore,it is recommended that DME should be early diagnosed and effective treatment.The research status at home and abroad and future development trends of DME treatment were summarized.