中华实验眼科杂志
中華實驗眼科雜誌
중화실험안과잡지
CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY
2013年
11期
1085-1088
,共4页
干眼%下穹隆结膜囊气泡%泪膜破裂时间%泪液分泌试验
榦眼%下穹隆結膜囊氣泡%淚膜破裂時間%淚液分泌試驗
간안%하궁륭결막낭기포%루막파렬시간%루액분비시험
Dry eye%Bubble in the inferior conjunctiva fornix%Tear film break-up time%Schirmer test
背景 泪膜不稳定伴随眼表温度升高及泪液蒸发增强均是眼表气泡产生和干眼发病的相关因素,但眼表气泡与干眼发病的关系尚缺少相关研究.眼表气泡在相对密闭的穹隆部结膜囊内存留时间长,在下穹隆结膜囊检查更方便. 目的 探讨眼下穹隆结膜囊气泡与干眼的关系. 方法 收集2012年1-5月于武汉科技大学附属天佑医院眼科门诊就诊的有多种眼表刺激症状且双眼下穹隆结膜囊有气泡者(气泡组)和双眼下穹隆结膜囊无气泡者(无气泡组)各32例64眼,两组患者的年龄及性别相匹配.患者在裂隙灯显微镜下进行下穹隆部气泡检查,所有患者均行泪膜破裂时间(BUT)和泪液分泌试验Ⅰ(SⅠt)检查,干眼的诊断参照刘祖国等的标准.两组患者BUT、SⅠt检查结果的差异比较采用独立样本t检验,两组患者干眼发生率的比较采用x2检验. 结果 气泡组64眼中干眼发生率为75.00％,BUT＜5 s且S Ⅰ t＜5 mm/5 min的发生率为46.88％,仅BUT＜5s的发生率为53.13％,仅S Ⅰ t＜5 mm/5 min的发生率为57.81％；无气泡组64眼中干眼的发生率为31.25％,BUT＜5s且S Ⅰ t＜5 mm/5 min的发生率为18.75％,仅BUT＜5s的发生率为21.88％,仅S Ⅰ t＜5 mm/5 min的发生率为20.31％,两组间差异均有统计学意义(均P=0.00).诊断为干眼的68眼中,气泡组48眼,占70.59％ (48/68)；无气泡组20眼,占29.41％ (20/68),二者间差异有统计学意义(x2=24.60,P＜0.01)；气泡组与无气泡组患者BUT＜5s的发生率、S Ⅰ t＜5 mm/5 min发生率的差异均无统计学意义(x2=0.01,P=0.95；x2=1.06,P=0.30).2个组间患者BUT检测值及SⅠt检测值的比较差异均无统计学意义(t=0.46,P=0.65;t=0.80,P=0.43).结论 干眼与眼下穹隆结膜囊气泡有显著的相关性.
揹景 淚膜不穩定伴隨眼錶溫度升高及淚液蒸髮增彊均是眼錶氣泡產生和榦眼髮病的相關因素,但眼錶氣泡與榦眼髮病的關繫尚缺少相關研究.眼錶氣泡在相對密閉的穹隆部結膜囊內存留時間長,在下穹隆結膜囊檢查更方便. 目的 探討眼下穹隆結膜囊氣泡與榦眼的關繫. 方法 收集2012年1-5月于武漢科技大學附屬天祐醫院眼科門診就診的有多種眼錶刺激癥狀且雙眼下穹隆結膜囊有氣泡者(氣泡組)和雙眼下穹隆結膜囊無氣泡者(無氣泡組)各32例64眼,兩組患者的年齡及性彆相匹配.患者在裂隙燈顯微鏡下進行下穹隆部氣泡檢查,所有患者均行淚膜破裂時間(BUT)和淚液分泌試驗Ⅰ(SⅠt)檢查,榦眼的診斷參照劉祖國等的標準.兩組患者BUT、SⅠt檢查結果的差異比較採用獨立樣本t檢驗,兩組患者榦眼髮生率的比較採用x2檢驗. 結果 氣泡組64眼中榦眼髮生率為75.00％,BUT＜5 s且S Ⅰ t＜5 mm/5 min的髮生率為46.88％,僅BUT＜5s的髮生率為53.13％,僅S Ⅰ t＜5 mm/5 min的髮生率為57.81％；無氣泡組64眼中榦眼的髮生率為31.25％,BUT＜5s且S Ⅰ t＜5 mm/5 min的髮生率為18.75％,僅BUT＜5s的髮生率為21.88％,僅S Ⅰ t＜5 mm/5 min的髮生率為20.31％,兩組間差異均有統計學意義(均P=0.00).診斷為榦眼的68眼中,氣泡組48眼,佔70.59％ (48/68)；無氣泡組20眼,佔29.41％ (20/68),二者間差異有統計學意義(x2=24.60,P＜0.01)；氣泡組與無氣泡組患者BUT＜5s的髮生率、S Ⅰ t＜5 mm/5 min髮生率的差異均無統計學意義(x2=0.01,P=0.95；x2=1.06,P=0.30).2箇組間患者BUT檢測值及SⅠt檢測值的比較差異均無統計學意義(t=0.46,P=0.65;t=0.80,P=0.43).結論 榦眼與眼下穹隆結膜囊氣泡有顯著的相關性.
배경 루막불은정반수안표온도승고급루액증발증강균시안표기포산생화간안발병적상관인소,단안표기포여간안발병적관계상결소상관연구.안표기포재상대밀폐적궁륭부결막낭내존류시간장,재하궁륭결막낭검사경방편. 목적 탐토안하궁륭결막낭기포여간안적관계. 방법 수집2012년1-5월우무한과기대학부속천우의원안과문진취진적유다충안표자격증상차쌍안하궁륭결막낭유기포자(기포조)화쌍안하궁륭결막낭무기포자(무기포조)각32례64안,량조환자적년령급성별상필배.환자재렬극등현미경하진행하궁륭부기포검사,소유환자균행루막파렬시간(BUT)화루액분비시험Ⅰ(SⅠt)검사,간안적진단삼조류조국등적표준.량조환자BUT、SⅠt검사결과적차이비교채용독립양본t검험,량조환자간안발생솔적비교채용x2검험. 결과 기포조64안중간안발생솔위75.00％,BUT＜5 s차S Ⅰ t＜5 mm/5 min적발생솔위46.88％,부BUT＜5s적발생솔위53.13％,부S Ⅰ t＜5 mm/5 min적발생솔위57.81％；무기포조64안중간안적발생솔위31.25％,BUT＜5s차S Ⅰ t＜5 mm/5 min적발생솔위18.75％,부BUT＜5s적발생솔위21.88％,부S Ⅰ t＜5 mm/5 min적발생솔위20.31％,량조간차이균유통계학의의(균P=0.00).진단위간안적68안중,기포조48안,점70.59％ (48/68)；무기포조20안,점29.41％ (20/68),이자간차이유통계학의의(x2=24.60,P＜0.01)；기포조여무기포조환자BUT＜5s적발생솔、S Ⅰ t＜5 mm/5 min발생솔적차이균무통계학의의(x2=0.01,P=0.95；x2=1.06,P=0.30).2개조간환자BUT검측치급SⅠt검측치적비교차이균무통계학의의(t=0.46,P=0.65;t=0.80,P=0.43).결론 간안여안하궁륭결막낭기포유현저적상관성.
Background Instability of tear film,increase of ocular surface temperature and tear evaporation are the associated factors of both bubbles and dry eye.But the relationship between dry eye and ocular surface bubbles is unclear.The bubbles are easily retained and checked in the inferior conjunctiva fornix.Objective This study aimed to study the relationship between dry eye and bubbles in the inferior conjunctiva fornix.Methods Sixty-four eyes of 32 patients with binocular irritative symptoms and bubbles or without bubbles in the inferior conjunctiva fornix were collected in Affiliated Tianyou Hospital of Wuhan University of Science and Technology from January to May,2012.The bubbles in the inferior conjunctiva fornix were examined by slit lamp microscope,and the break-up time (BUT) and Schirmer Ⅰ test (S Ⅰ t) were performed.The differences of BUT and S Ⅰ t between the two groups were compared using independent sample t test,and abnormality rate of examination indexes was statistical analyzed by CHI-Square test using a SPSS 11.5 software.Written informed consent was obtained prior to the clinical survey.Results In the 64 eyes of the bubbles group,incidence of dry eye was 75.00％,and the incidence of both BUT＜5 seconds and S Ⅰ t＜5 mm/5 minutes was 46.88％ ;while the incidence of BUT＜5 seconds or S Ⅰ t＜5 mm/5 minutes was 53.13％ and 57.81％,respectively.In 64 eyes without bubbles,incidence of dry eye was 31.25％,the incidence of both BUT＜5 seconds and S Ⅰ t＜5 mm/5 minutes was 18.75％,that of BUT＜5 seconds or S Ⅰ t＜5 mm/5 minutes was 21.88％ and 20.31％,respectively.The incidences of dry eye,both BUT＜5 seconds and S Ⅰ t＜5 mm/5 minutes,BUT ＜5 seconds,S Ⅰ t＜5 mm/5 minutes were significantly higher in the bubbles group than those of the without bubbles group (all at P=0.00).In the 68 eyes determined as dry eyes,48 eyes (48/68) were in the bubbles group and 20eyes (20/68) were in the without bubbles group,showing a significant difference between the two groups (x2 =24.60,P＜0.01).The incidences of both BUT＜5 seconds,S Ⅰ t＜5 mm/5 minutes were not significantly different between the two groups (x2 =0.01,P=0.95;x2 =1.06,P=0.30).Conclusions The bubbles in the inferior conjunctiva fornix is highly correlated with dry eye.
