CAJ | 학술논문

非可控性炎症在多种疾病的发生发展中起到重要作用.糖尿病视网膜病变(DR)是一种低度慢性炎症性疾病,确切地说可能是一种非可控性炎症.DR中的中性粒细胞不能及时凋亡或被清除、不同表型的巨噬细胞同时存在、周细胞功能减弱、Th1细胞反应降低等细胞因素致DR炎症不易缓解.与此同时,抗炎型可溶性因子含量的降低,如白细胞介素-10(IL-10)、转化生长因子-β(TGF-β)、一氧化氮(NO)、环氧化二十碳三烯甘油酸(EETs)、脂氧素等进一步使炎症持续.此外高糖条件下产生的脂质代谢产物、糖基化终末产物、活性氧中间产物(ROI)等持续存在的刺激因素均可导致炎症不能缓解.对DR炎症发病机制的深入理解有助于探索新的治疗途径,延缓其发生发展.
비가공성염증재다충질병적발생발전중기도중요작용.당뇨병시망막병변(DR)시일충저도만성염증성질병,학절지설가능시일충비가공성염증.DR중적중성립세포불능급시조망혹피청제、불동표형적거서세포동시존재、주세포공능감약、Th1세포반응강저등세포인소치DR염증불역완해.여차동시,항염형가용성인자함량적강저,여백세포개소-10(IL-10)、전화생장인자-β(TGF-β)、일양화담(NO)、배양화이십탄삼희감유산(EETs)、지양소등진일보사염증지속.차외고당조건하산생적지질대사산물、당기화종말산물、활성양중간산물(ROI)등지속존재적자격인소균가도치염증불능완해.대DR염증발병궤제적심입리해유조우탐색신적치료도경,연완기발생발전.
Nonresolving inflammation plays an important role in the onset and development of various diseases.Diabetic retinopathy (DR) is a low-degree chronic inflammatory process,and actually it would be a nonresolving inflammatory disease.Failure of neutrophils apoptosis in time,converting failure of macrophages from a pro-inflammatory to anti-inflammatory phenotype,dysfunction of pericytes and poor activation of Thl cells are all contributed to inflammatory prolong.Meanwhile the low concentration of anti-inflammatory soluble factors such as interleukin-10 (IL-10),transforming growth factor-β (TGF-β),nitric oxide (NO),epoxyeicosatrienoic acids (EETs)and lipoxins in serum or ocular specimen are also benefit to failure of inflammatory resolution.In addition,persistent stimulation such as lipid products,advanced glycation end products(AGEs) and reactive oxygen intermediate (ROI)deteriorate the inflammation persistently.More understanding of DR pathogenesis greatly complicates the development of anti-inflammatory therapy.