CAJ | 학술논문

多巴胺是中枢神经递质之一,在人体内与相应的膜受体结合后可激活或抑制环磷酸腺苷(cAMP)的活性,从而调控细胞的钙信号；同时多巴胺也是视网膜中一种主要的神经递质与调质,在整个视觉通路中参与视觉系统的信号传递与调控过程,如视网膜、外侧膝状体、视皮层等.近年来研究发现,多巴胺量的变化影响弱视、近视眼的形成,此外,它还通过与受体结合参与眼压的调控,这些研究对眼科临床上弱视的治疗、近视的预防和眼压的控制等方面提供了新的思路.就视网膜中多巴胺在调控形觉剥夺、光学离焦诱导的近视眼形成、眼压的调节、眼轴的发育及弱视的形成与治疗等方面的研究进展进行综述.
다파알시중추신경체질지일,재인체내여상응적막수체결합후가격활혹억제배린산선감(cAMP)적활성,종이조공세포적개신호；동시다파알야시시망막중일충주요적신경체질여조질,재정개시각통로중삼여시각계통적신호전체여조공과정,여시망막、외측슬상체、시피층등.근년래연구발현,다파알량적변화영향약시、근시안적형성,차외,타환통과여수체결합삼여안압적조공,저사연구대안과림상상약시적치료、근시적예방화안압적공제등방면제공료신적사로.취시망막중다파알재조공형각박탈、광학리초유도적근시안형성、안압적조절、안축적발육급약시적형성여치료등방면적연구진전진행종술.
Dopamine is one of neurotransmitters of the central nervous system,and it can activate or inhibit cAMP by binding the corresponding membrane receptor and further regulate calcium signals.Dopamine is also primary neurotransmitter and modulator in retina,and it plays very important roles over the entire visual pathway including retina,lateral geniculate body and visual cortex.Recent study showed that dopamine participates in the pathogenesis of amblyopia and myopia.In addition,it is also involved in the regulation of intraocular pressure (IOP).These studies offered some new clues for the treatment and prevention of amblyopia and myopia as well as the regulation of IOP.Hence,this paper describes the new progress of retinal dopamine in the form deprivation myopia,myopic defocus,the regulation of IOP,the eye growth and the treatment of amblyopia.