中华实验眼科杂志
中華實驗眼科雜誌
중화실험안과잡지
CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY
2014年
8期
743-747
,共5页
吴静%崔裕波%侯光辉%王超%张日佳%祁冰
吳靜%崔裕波%侯光輝%王超%張日佳%祁冰
오정%최유파%후광휘%왕초%장일가%기빙
白塞病%白细胞介素-1%基因多态性%Meta分析
白塞病%白細胞介素-1%基因多態性%Meta分析
백새병%백세포개소-1%기인다태성%Meta분석
Beh(c)et disease%Interleukin-1%Polymorphism%Meta analysis
背景 白细胞介素-1(IL-1) α-889C/T、IL-1 β-511C/T、+3962C/T和IL-1Ra-2是IL-1基因的不同位点.IL-1基因的多态性与白塞病之间的潜在相关性已经在不同的人群中进行了研究,但研究结果存在一定的争议. 目的 对已发表的关于IL-1基因多态性与白塞病之间关联性的文献进行二次分析,探讨IL-1基因多态性是否增加白塞病的易感性.方法 按照检索策略检索2013年5月31日之前公开发表的关于IL-1基因多态性与白塞病之间关联性的研究文献,检索途径包括Medline、EMBASE、Cochrane Library、Web ofknowledge、Google Scholar、中国知网和万方数据库,发表语种限于英文和中文,研究设计包括病例对照研究.筛选出符合标准的文献,根据Newcastle-Ottawa Scale(NOS)量表(共9分)评价纳入文献的研究质量.分析IL-1 α-889TT基因型、IL-1β-3962C等位基因、IL-1β-511T表型基因和IL-1Ra-2等位基因与白塞病易感性间的关联性,用RevMan5.0统计学软件进行统计学分析.对7篇研究中异质性低(I2＜50％)的指标采用固定效应模型评价各指标的合并效应量,异质性高(I2＞50％)的指标用随机效应模型评价合并效应量.结果 共检索到相关文献370篇,经过阅读摘要和全文共纳入7篇符合纳入标准的研究文献,NOS量表评分均≥8分.7篇文献共包括白塞病患者499例和正常人708名,结果发现IL-1-3962C等位基因多态性增加白塞病的风险(OR=1.41,95％ CI:1.06 ～ 1.88,P=0.02),IL-1 α-889TT表型基因的多态性降低白塞病的风险(OR=0.61,95％CI:0.40～0.92,P=0.02),而IL-1-51 1T等位基因(OR=0.84,95％ CI:0.58 ～1.23,P=0.38)和IL-1 Ra-2等位基因(OR=1.25,95％ CI:0.50 ～3.14,P=0.63)与白塞病之间均无明显关联. 结论 IL-1基因多态性与白塞病易感性之间可能具有一定的相关性,但还需要大样本量的临床研究进一步验证.
揹景 白細胞介素-1(IL-1) α-889C/T、IL-1 β-511C/T、+3962C/T和IL-1Ra-2是IL-1基因的不同位點.IL-1基因的多態性與白塞病之間的潛在相關性已經在不同的人群中進行瞭研究,但研究結果存在一定的爭議. 目的 對已髮錶的關于IL-1基因多態性與白塞病之間關聯性的文獻進行二次分析,探討IL-1基因多態性是否增加白塞病的易感性.方法 按照檢索策略檢索2013年5月31日之前公開髮錶的關于IL-1基因多態性與白塞病之間關聯性的研究文獻,檢索途徑包括Medline、EMBASE、Cochrane Library、Web ofknowledge、Google Scholar、中國知網和萬方數據庫,髮錶語種限于英文和中文,研究設計包括病例對照研究.篩選齣符閤標準的文獻,根據Newcastle-Ottawa Scale(NOS)量錶(共9分)評價納入文獻的研究質量.分析IL-1 α-889TT基因型、IL-1β-3962C等位基因、IL-1β-511T錶型基因和IL-1Ra-2等位基因與白塞病易感性間的關聯性,用RevMan5.0統計學軟件進行統計學分析.對7篇研究中異質性低(I2＜50％)的指標採用固定效應模型評價各指標的閤併效應量,異質性高(I2＞50％)的指標用隨機效應模型評價閤併效應量.結果 共檢索到相關文獻370篇,經過閱讀摘要和全文共納入7篇符閤納入標準的研究文獻,NOS量錶評分均≥8分.7篇文獻共包括白塞病患者499例和正常人708名,結果髮現IL-1-3962C等位基因多態性增加白塞病的風險(OR=1.41,95％ CI:1.06 ～ 1.88,P=0.02),IL-1 α-889TT錶型基因的多態性降低白塞病的風險(OR=0.61,95％CI:0.40～0.92,P=0.02),而IL-1-51 1T等位基因(OR=0.84,95％ CI:0.58 ～1.23,P=0.38)和IL-1 Ra-2等位基因(OR=1.25,95％ CI:0.50 ～3.14,P=0.63)與白塞病之間均無明顯關聯. 結論 IL-1基因多態性與白塞病易感性之間可能具有一定的相關性,但還需要大樣本量的臨床研究進一步驗證.
배경 백세포개소-1(IL-1) α-889C/T、IL-1 β-511C/T、+3962C/T화IL-1Ra-2시IL-1기인적불동위점.IL-1기인적다태성여백새병지간적잠재상관성이경재불동적인군중진행료연구,단연구결과존재일정적쟁의. 목적 대이발표적관우IL-1기인다태성여백새병지간관련성적문헌진행이차분석,탐토IL-1기인다태성시부증가백새병적역감성.방법 안조검색책략검색2013년5월31일지전공개발표적관우IL-1기인다태성여백새병지간관련성적연구문헌,검색도경포괄Medline、EMBASE、Cochrane Library、Web ofknowledge、Google Scholar、중국지망화만방수거고,발표어충한우영문화중문,연구설계포괄병례대조연구.사선출부합표준적문헌,근거Newcastle-Ottawa Scale(NOS)량표(공9분)평개납입문헌적연구질량.분석IL-1 α-889TT기인형、IL-1β-3962C등위기인、IL-1β-511T표형기인화IL-1Ra-2등위기인여백새병역감성간적관련성,용RevMan5.0통계학연건진행통계학분석.대7편연구중이질성저(I2＜50％)적지표채용고정효응모형평개각지표적합병효응량,이질성고(I2＞50％)적지표용수궤효응모형평개합병효응량.결과 공검색도상관문헌370편,경과열독적요화전문공납입7편부합납입표준적연구문헌,NOS량표평분균≥8분.7편문헌공포괄백새병환자499례화정상인708명,결과발현IL-1-3962C등위기인다태성증가백새병적풍험(OR=1.41,95％ CI:1.06 ～ 1.88,P=0.02),IL-1 α-889TT표형기인적다태성강저백새병적풍험(OR=0.61,95％CI:0.40～0.92,P=0.02),이IL-1-51 1T등위기인(OR=0.84,95％ CI:0.58 ～1.23,P=0.38)화IL-1 Ra-2등위기인(OR=1.25,95％ CI:0.50 ～3.14,P=0.63)여백새병지간균무명현관련. 결론 IL-1기인다태성여백새병역감성지간가능구유일정적상관성,단환수요대양본량적림상연구진일보험증.
Background Interleukin (IL)-1a-889C/T,IL-1β-S11C/T,+ 3962C/T and IL-1Ra-2 are different morphology of single nucleotide of interleuki-1 (IL-1).The potential relationship of IL-1 polymorphisms with Beh(c)et disease has been studied in several populations and groups.However,study outcomes are controversial for a long duration.Objective This Meta-analysis was to determine whether the IL-1 gene polymorphisms is associated with the pathogenesis and development of Beh(c)et disease.Methods The literature of the assoiation between IL-1 polymorphisms and Beh(c)et disease was retrieved from Medline,EMBASE,Cochrane Library,Web of knowledge,Google Scholar,Wanfang and CNKI databases.All the published original articles (case-control studies) were reviewed with the deadline May 31,2013,and the languages were limited to English and Chinese.Included reports were evaluated based on Newcastle-Ottawa Scale (NOS) score.The potential influence of IL-1α-889TT gene,IL-1β-3962C,IL-1β-511T and IL-1Ra-2 polymorphisms on Beh(c)et disease were analyzed.RevMan5.0,the Cochrane collaboration software program,was used to prepare and complete this review.The effect size was assessed using fixed effect model in the index with lower heterogeneity (I2 ＜50％) or randomized effect model in the index with higher heterogeneity (I2＞50％).Results The literature search resulted a total of 370 cases-controlled studies,and 7 studies met the included criteria,with the NOS scores ≥ 8.The total patients were 499 and normal controls were 708.Meta-analysis was performed on several populations.Overall,the polymorphisms of IL-1β-3962C allele increased the susciptibility of Beh(c)et disease (OR =1.41,95％ CI:1.06-1.88,P =0.02),and IL-1α-889TT genotype reduced the risk of Beh(c)et disease (OR =0.61,95 ％ CI:0.40-0.92,P =0.02).However,There was no significant association between variants of IL-1β-511T allele (OR =0.84,95％ CI:0.58-1.23,P=0.38) or IL-1RA-2 allele (OR =1.25,95％ CI:0.50-3.14,P=0.63) and Beh(c)et disease susciptibility.Conclusions These results suggest that Beh(c)et disease is associated with the IL-1 gene polymorphisms at the locations α-889C/T and β-3962C/T.A larger sample size clinical data still are need to confirm this conclusion.
