中华实验眼科杂志
中華實驗眼科雜誌
중화실험안과잡지
CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY
2014年
9期
860-864
,共5页
基质金属蛋白酶%基质金属蛋白酶组织抑制剂%糖尿病/并发症%视网膜病变%白内障%角膜病变
基質金屬蛋白酶%基質金屬蛋白酶組織抑製劑%糖尿病/併髮癥%視網膜病變%白內障%角膜病變
기질금속단백매%기질금속단백매조직억제제%당뇨병/병발증%시망막병변%백내장%각막병변
Matrix metalloproteinase%Tissue inhibitior of metalloproteinase%Diabetic mellitus/complication%Retinopathy%Cataract%Keratopathy
基质金属蛋白酶/基质金属蛋白酶组织抑制剂(MMPs/TIMPs)系统是降解和重塑细胞外基质(ECM)最重要的酶系统,它参与调节眼的一些生理和病理过程,如眼的发育、炎症、伤口愈合、新生血管形成、肿瘤转移等,与多种眼病,如增生性玻璃体视网膜病变、增生型糖尿病视网膜病变、糖尿病性白内障、孔源性视网膜脱离、视网膜母细胞瘤、年龄相关性黄斑变性、眼外伤、青光跟等的发生密切相关.就MMPs/TIMPs系统的生物学特性及其在糖尿病眼部并发症研究方面的应用进行综述.
基質金屬蛋白酶/基質金屬蛋白酶組織抑製劑(MMPs/TIMPs)繫統是降解和重塑細胞外基質(ECM)最重要的酶繫統,它參與調節眼的一些生理和病理過程,如眼的髮育、炎癥、傷口愈閤、新生血管形成、腫瘤轉移等,與多種眼病,如增生性玻璃體視網膜病變、增生型糖尿病視網膜病變、糖尿病性白內障、孔源性視網膜脫離、視網膜母細胞瘤、年齡相關性黃斑變性、眼外傷、青光跟等的髮生密切相關.就MMPs/TIMPs繫統的生物學特性及其在糖尿病眼部併髮癥研究方麵的應用進行綜述.
기질금속단백매/기질금속단백매조직억제제(MMPs/TIMPs)계통시강해화중소세포외기질(ECM)최중요적매계통,타삼여조절안적일사생리화병리과정,여안적발육、염증、상구유합、신생혈관형성、종류전이등,여다충안병,여증생성파리체시망막병변、증생형당뇨병시망막병변、당뇨병성백내장、공원성시망막탈리、시망막모세포류、년령상관성황반변성、안외상、청광근등적발생밀절상관.취MMPs/TIMPs계통적생물학특성급기재당뇨병안부병발증연구방면적응용진행종술.
The matrix metalloproteinases/tissue inhibitors of metalloproteinase (MMPs/TIMPs) system plays an important role in the degradation and remodel of the extracellular matrix (ECM).MMPs/TIMPs system is associated with ocular physiological process,such as ocular growth and development,etc.Also,MMPs/TIMPs system is involved in ocular pathological process including inflammation,wound healing,neoangiogenesis,tumor invasion and metastasis.MMPs/TIMPs system also participats in the formation of some ophthalmic diseases such as proliferative vitreoretinopathy (PVR),proliferative diabetic retinopathy (PDR),diabetic cataract,rhegmatogenous retinal detachment (RRD),retinoblastoma (RB),age-related macular degeneration (AMD),ocular trauma,and glaucoma.This review attempts to elaborate the biological characteristics of MMPs/TIMPs,and the current researches of MMPs/ TIMPs system in the diabetic ocular complications,focusing on diabetic retinopathy,cataract and keratopathy.
