CAJ | 학술논문

过氧化物酶体增生物激活受体(PPA Rs)是配体依赖的核激素受体超家族成员转录因子,目前已有PPARα、PPARβ/δ和PPARγ 3种亚型,其中PPARγ与纤维化疾病的关系日益引起人们的关注.PPARγ由激动剂激活后通过控制炎症反应、抑制细胞的增生、诱导细胞的凋亡和分化、抑制血管形成及抗氧化等不同机制发挥抗纤维化作用,有望成为眼部纤维化疾病治疗的一个新途径.从PPARs及其分布、PPARγ的结构与功能、PPARγ配体及激动剂、PPARγ的活化、PPARγ在眼组织的表达、PPARγ与眼部疾病几个方面就PPARγ及其激动剂在眼部疾病中的作用进行综述.
과양화물매체증생물격활수체(PPA Rs)시배체의뢰적핵격소수체초가족성원전록인자,목전이유PPARα、PPARβ/δ화PPARγ 3충아형,기중PPARγ여섬유화질병적관계일익인기인문적관주.PPARγ유격동제격활후통과공제염증반응、억제세포적증생、유도세포적조망화분화、억제혈관형성급항양화등불동궤제발휘항섬유화작용,유망성위안부섬유화질병치료적일개신도경.종PPARs급기분포、PPARγ적결구여공능、PPARγ배체급격동제、PPARγ적활화、PPARγ재안조직적표체、PPARγ여안부질병궤개방면취PPARγ급기격동제재안부질병중적작용진행종술.
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily of ligand-dependent transcription factors.To date,three isotypes of PPARs called PPARα,PPARγ and PPARβ/δ have been identified.The relationship between PPARγ and fibrosis disease has increasingly drawn people's attention.PPARγ is activated by its ligands or agonists plays an important role in the control of fibrosis through their effects on various cellular processes,including anti-inflammatory,inducing cellular apoptosis and differentiation,anti angiogenesis,antioxidative and anti-proliferative effects,which is expected to be a new way to treat ocular diseases.The role of PPAR-γ and its agonist in ocular diseases,including PPARs and its distribution,the structure and function of PPAR-γ,PPAR-γ ligands and agonist,activation of PPAR-γ,PPAR-γ in the expression of eye tissues,and the role of PPAR-γ and its agonist in ocular diseases were reviewed.