CAJ | 학술논문

人类自身免疫性葡萄膜炎是一组常见的眼部炎症性疾病,不明因素导致的自身免疫紊乱可对眼部组织产生不可逆性损害,因此长期以来,对人类自身免疫性葡萄膜炎的致病原因、发病机制的研究从未停止.以往的研究认为,1型辅助性T细胞群(Th1)是诱发人类自身免疫性葡萄膜炎的关键因素,但近年来发现,Th17是诱导自身免疫性葡萄膜炎病变的主要因素.由于每种Th细胞群都有其特定的细胞因子及转录因子,这些细胞因子通过调节Th1、Th2、Th17的表达及平衡决定着自身免疫性葡萄膜炎的发生和发展.研究Th1及Th17相关细胞因子在病变中的作用是探讨自身免疫性葡萄膜炎发生和发展的重要基础之一.就近年来Th1及Th17主要的相关细胞因子在葡萄膜炎的致病性、调节及治疗作用方面的研究进展进行综述.
인류자신면역성포도막염시일조상견적안부염증성질병,불명인소도치적자신면역문란가대안부조직산생불가역성손해,인차장기이래,대인류자신면역성포도막염적치병원인、발병궤제적연구종미정지.이왕적연구인위,1형보조성T세포군(Th1)시유발인류자신면역성포도막염적관건인소,단근년래발현,Th17시유도자신면역성포도막염병변적주요인소.유우매충Th세포군도유기특정적세포인자급전록인자,저사세포인자통과조절Th1、Th2、Th17적표체급평형결정착자신면역성포도막염적발생화발전.연구Th1급Th17상관세포인자재병변중적작용시탐토자신면역성포도막염발생화발전적중요기출지일.취근년래Th1급Th17주요적상관세포인자재포도막염적치병성、조절급치료작용방면적연구진전진행종술.
Human autoimmune uveitis encompasses a diverse group of common ocular inflammatory diseases.Unknown factors trigger the breakdown of self-tolerance and subsequently lead to the irreversible vision impairment.So the explore and research has never ceased for a long time.Previous study indicated that T helper lymphocyte 1 (Th1) plays a key role in the pathogenesis and development of human autoimmune uveitis.But recently accumulating evidences from both animal and clinical studies suggest that Th17 participates in the pathological mechanism of human autoimmune uveitis.Studies showed that Th1 and Th17 determine the pathological process by the regulation signal of specific cytokines and transcription factors.More and more evidences revealed that Th1 and Th17 are the predominant influences in induction of uveitis.Unveiling the roles of Th1/Th17-related cytokines will help to elucidate the mechanism and progression of uveitis.Recent findings of Th1/Th17-related cytokines regarding pathogenesis and regulation attributed in uveitis were summarized and the novel viewpoint of treatments was discussed.