CAJ | 학술논문

糖尿病视网膜病变(DR)是糖尿病患者视力损害的主要原因.近年来,DR相关信号通路的研究更好地揭示了DR的发病机制,为DR的临床治疗研究提供了新的思路,为开发靶向治疗的药物提供了理论依据.阐明生物信号通路在DR发生和发展中的生物学功能,有助于临床医师正确进行医疗决策,选择性、针对性地对其进行干预,大大改善DR的治疗效果.如何在医疗实践中将信号通路的研究和靶向治疗结合起来是推进DR治疗的重要环节.因此我们应注重转化医学研究,重视信号通路研究对靶向治疗的引导作用,使医学基础研究与临床应用研究有机结合起来.
당뇨병시망막병변(DR)시당뇨병환자시력손해적주요원인.근년래,DR상관신호통로적연구경호지게시료DR적발병궤제,위DR적림상치료연구제공료신적사로,위개발파향치료적약물제공료이론의거.천명생물신호통로재DR발생화발전중적생물학공능,유조우림상의사정학진행의료결책,선택성、침대성지대기진행간예,대대개선DR적치료효과.여하재의료실천중장신호통로적연구화파향치료결합기래시추진DR치료적중요배절.인차아문응주중전화의학연구,중시신호통로연구대파향치료적인도작용,사의학기출연구여림상응용연구유궤결합기래.
Diabetic retinopathy (DR) is one of common causes of vision loss.Recent years,progress has been made on the signal pathway in DR which provides more theoretical basis for clinical therapies and more chance for developing targeted therapeutic drugs.Understanding the biological function of the signal pathway in DR is helpful for physicians to selectively control its biological activities,make medical decisions and optimize new approaches to the treatment of DR.How to closely combine the study of signal pathway and targeted therapy in practice is a key link of improving the therapeutic effect of DR.Therefore,we should pay attention to translational medicine and reinforce targeted therapy in DR.