中华眼视光学与视觉科学杂志
中華眼視光學與視覺科學雜誌
중화안시광학여시각과학잡지
CHINESE JOURNAL OF OPTOMETRY OPHTHALMOLOGY AND VISUAL SCIENCE
2013年
10期
612-615
,共4页
宋鹏%隋文婕%丁刚%贾艳妮%李素霞%高华
宋鵬%隋文婕%丁剛%賈豔妮%李素霞%高華
송붕%수문첩%정강%가염니%리소하%고화
甘油%角膜中期保存液%角膜移植,深板层%化脓性角膜炎%并发症
甘油%角膜中期保存液%角膜移植,深闆層%化膿性角膜炎%併髮癥
감유%각막중기보존액%각막이식,심판층%화농성각막염%병발증
Glycerin%Corneal medium-term preservative%Corneal transplantation,deep anteriorlamellar%Purulent keratitis%Complications
目的 对比新鲜与甘油冷冻保存角膜供体对深板层角膜移植治疗化脓性角膜炎术后临床恢复的影响.方法 回顾性病例研究.2011年1月至2012年8月,在山东省眼科医院成功施行深板层角膜移植术(DALK)的化脓性角膜炎患者32例(32眼).根据供体保存方式,分为新鲜供体组(FCT)13例与甘油供体组(GCCT)19例.采集供体资料,记录术后并发症、植片情况及屈光状态等.采用独立样本t检验对数据进行分析.结果 术后角膜上皮愈合完整时间,新鲜供体组为(3.8±2.1)d,甘油供体组为(7.3±2.7)d,差异有统计学意义(t=-3.764,P＜0.05).植片水肿消退时间,新鲜供体组为(5.7±2.6)d,甘油供体组为(10.4±3.0)d,差异有统计学意义(t=-4.348,P＜0.01).随访期内甘油供体组有3例发生植片上皮缺损,对症治疗后植片上皮缺损愈合.23例(23眼,除外白内障及先天性弱视)术后最佳矫正视力均恢复至20/63～20/25,新鲜供体组和甘油供体组的平均视力分别为(0.25±0.12)logMAR、(0.28±0.17)logMAR,2组差异无统计学意义(t=-1.428,P＞0.05).结论 甘油保存供体用于DALK术治疗化脓性角膜炎,角膜上皮愈合及角膜水肿消退时间较新鲜供体慢.及时合理处理并发症,可以获得与新鲜供体相似的屈光愈后.
目的 對比新鮮與甘油冷凍保存角膜供體對深闆層角膜移植治療化膿性角膜炎術後臨床恢複的影響.方法 迴顧性病例研究.2011年1月至2012年8月,在山東省眼科醫院成功施行深闆層角膜移植術(DALK)的化膿性角膜炎患者32例(32眼).根據供體保存方式,分為新鮮供體組(FCT)13例與甘油供體組(GCCT)19例.採集供體資料,記錄術後併髮癥、植片情況及屈光狀態等.採用獨立樣本t檢驗對數據進行分析.結果 術後角膜上皮愈閤完整時間,新鮮供體組為(3.8±2.1)d,甘油供體組為(7.3±2.7)d,差異有統計學意義(t=-3.764,P＜0.05).植片水腫消退時間,新鮮供體組為(5.7±2.6)d,甘油供體組為(10.4±3.0)d,差異有統計學意義(t=-4.348,P＜0.01).隨訪期內甘油供體組有3例髮生植片上皮缺損,對癥治療後植片上皮缺損愈閤.23例(23眼,除外白內障及先天性弱視)術後最佳矯正視力均恢複至20/63～20/25,新鮮供體組和甘油供體組的平均視力分彆為(0.25±0.12)logMAR、(0.28±0.17)logMAR,2組差異無統計學意義(t=-1.428,P＞0.05).結論 甘油保存供體用于DALK術治療化膿性角膜炎,角膜上皮愈閤及角膜水腫消退時間較新鮮供體慢.及時閤理處理併髮癥,可以穫得與新鮮供體相似的屈光愈後.
목적 대비신선여감유냉동보존각막공체대심판층각막이식치료화농성각막염술후림상회복적영향.방법 회고성병례연구.2011년1월지2012년8월,재산동성안과의원성공시행심판층각막이식술(DALK)적화농성각막염환자32례(32안).근거공체보존방식,분위신선공체조(FCT)13례여감유공체조(GCCT)19례.채집공체자료,기록술후병발증、식편정황급굴광상태등.채용독립양본t검험대수거진행분석.결과 술후각막상피유합완정시간,신선공체조위(3.8±2.1)d,감유공체조위(7.3±2.7)d,차이유통계학의의(t=-3.764,P＜0.05).식편수종소퇴시간,신선공체조위(5.7±2.6)d,감유공체조위(10.4±3.0)d,차이유통계학의의(t=-4.348,P＜0.01).수방기내감유공체조유3례발생식편상피결손,대증치료후식편상피결손유합.23례(23안,제외백내장급선천성약시)술후최가교정시력균회복지20/63～20/25,신선공체조화감유공체조적평균시력분별위(0.25±0.12)logMAR、(0.28±0.17)logMAR,2조차이무통계학의의(t=-1.428,P＞0.05).결론 감유보존공체용우DALK술치료화농성각막염,각막상피유합급각막수종소퇴시간교신선공체만.급시합리처리병발증,가이획득여신선공체상사적굴광유후.
Objective To compare the outcomes of using fresh and glycerin-cryopreserved corneal tissue in treating purulent keratitis with deep anterior lamellar keratoplasty.Methods This was a retrospective case series study.Thirty-two patients (32 eyes) with purulent keratitis successfully underwent deep anterior lamellar keratoplasty (DALK) in Shandong Eye Hospital from January 2011 to August 2012.Based on the method for preserving corneal tissue,all patients were divided into a fresh corneal tissue (FCT) group (13 cases) and a glycerin-cryopreserved corneal tissue (GCCT) group (19 cases).Data on donor,complications,graft status and visual outcome were collected.An independent samples t test analysis was used to analyze the data.Results The amount of time for the epithelium graft to heal in the FCT group and GCCT group were 3.8±2.2 d and 7.3±2.7 d (t=-3.764,P＜0.05).The amount of time for the graft edema to disappear in the FCT group and GCCT group were 5.7±2.6 d and 10.4±3.0 d (t=-4.348,P＜0.01).In the follow-up phase,3 cases of graft epithelium defects occurred in the GCCT group and were healed with symptomatic treatment.After the surgery,the best corrected visual acuity (BCVA) of 23 patients (excluding cataract and congenital amblyopia) improved to 20/63-20/25,the mean BCVAs of the FCT and GCCT groups were 0.25±0.12 logMAR and 0.28±0.17 logMAR,respectively (t=-1.428,P＞0.05).Conclusion When glycerin-cryopreserved corneal tissue is used to treat purulent keratitis in DALK,the amount of time for the epithelium to heal and corneal edema to disappear took longer than with fresh corneal tissue.If potential or actual complications in GCCT group were treated in a timely and reasonable manner,similar outcomes would be obtained as for the FCT group.
